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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 1993.1
- 수록면
- 39 - 39 (1page)
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초록· 키워드
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To find out the novel anticancer agent for the treatment of solid tumors, 1-arylsulfonyl-2-alkoxy-4-arylimidazolines were designed and prepared from substituted styrenes through three steps. Compared to 5-fluorouracil, these analogues exhibit moderate cytotoxicity against human solid tumor cell lines, A-549(lung carcinoma) and SK-Mel-2(malignant melanoma). The structure-activity relationship indicates the high potential of this series for the development of novel antineoplastic agent.
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