STRUCTURE, SYNTHESIS, AND BIOLOGICAL FUNCTION OF NATURAL PRODUCTS IN DEER ANTLER AND THEIR DERIVATIVES

Kim, So-Yeon; Jhon, Gil-Ja; Lee, Yoon-Jin; Cho, So-Hye; Han, So-Yeop

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자료유형: 학술대회자료

저자정보: Kim, So-Yeon (Department of Chemistry, Ewha Womans University) Jhon, Gil-Ja (Department of Chemistry, Ewha Womans University) Lee, Yoon-Jin (Department of Chemistry, Ewha Womans University) Cho, So-Hye (Department of Chemistry, Ewha Womans University) Han, So-Yeop (Department of Chemistry, Ewha Womans University)

저널정보: 한국응용약물학회 한국응용약물학회 추계학술발표논문집 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products

발행연도: 1998.1

수록면: 126 - 126 (1page)

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Studies on natural products are of great interest, due to the limits in development of synthesized medicine and its side effects. Deer antler is the most popular cure-all type drug among Asian folk medicines. In this study, we newly isolated the biologically active components from chloroform extract and 70% ethanol extract of deer antler, and analyzed their structures. First, the structure of monoacetyldiglyceride in deer antler was identified. To investigate the structure-activity relationship of monoacetyldiglycerides, we synthesized diverse substituted glycerides from glycerol, and confirmed their structures by spectroscopic methods. Among seven structurally-interesting compounds tested in this study, compound 1,2,3,5, and 6 showed activity toward [Ca$\^$2+/]$\_$i/ increase in fura-2 loaded rat pancreatic acinar cells. Second, 70% ethanol extract of deer antler stimulated insulin release from rat pancreatic islets. We found the most effective fraction was CN-Es-8 in 70% ethanol extract, and it increased intracellular Ca$\^$2+/ concentration in pancreatic ${\beta}$-cell.

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