지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 74 - 74 (1page)
이용수
초록· 키워드
오류제보하기
Embryonic stem cells have several characteristics suitable for cell replacement therapy. To investigate a possibility of using human embryonic stem cell (hESC) as a carrier of therapeutic gene(s), hESC (MB03) was co-transfected with cDNAS coding for tyrosine hydroxylase (TH) and GTP cyclohydrolase Ⅰ (GTPCH Ⅰ) and bulk-selected using neomycin and hygromycin-B. Successful transfection was confirmed by western immunoblotting and RT-PCR. The genetically modified hESC (bk-THGC) relieved apomorphine-induced asymmetric motor behavior by approximately 54% when grafted into striatum of 6-OHDA-denervated rat brain. The number of rotation, however, increased up to 176+18% in 6 weeks when sham-grafted compared with number of rotation before graft. Immunohistochemical staining revealed that the grafted hESC survived and expressed TH for at least 6 weeks while the experiment was continued.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Human Embryonic Stem Cells Co-Transfected with Tyrosine Hydroxylase and GTP Cyclohydrolase Relieve Symptomatic Motor Behavior in a Rat Model of Parkinson's Disease
한국수정란이식학회 심포지움
2003 .01
-
In Vitro Neural Cell Differentiation of Genetically Modified Human Embryonic Stem Cells Expressing Tyrosine Hydroxylase
한국동물번식학회 학술대회
2004 .01
-
Feeder-free에서 배양된 인간배아줄기세포의 직접분화유도 방법을 이용한 간엽줄기세포로의 분화
한국동물번식학회지
2010 .01
-
Improvement of Motor Behavior of Parkinson's Disease Animal Model by Nurr1-Transfected Human Embryonic Stem Cells
한국수정란이식학회 심포지움
2004 .01
-
In Vitro Differentiation-induced hES Cells Relieve Symptomatic Motor Behavior of PD Animal Model
한국수정란이식학회 심포지움
2002 .01
-
Passaging Method for Expansion of Undifferentiated Human Embryonic Stem Cells by Pipetting Technique
한국동물번식학회지
2006 .01
-
Improvement of Motor Behavior of Parkinson's Disease Animal Model by Nurr1 Transfected Human Embryonic Stem Cells
한국동물번식학회 학술대회
2004 .01
-
다중 역전사 중합효소 연쇄 반응(Multiplex RT-PCR)을 이용한 인간배아 줄기세포 및 유도만능 줄기세포의 효과적인 분화 양상 조사
한국동물번식학회지
2011 .01
-
Improvement of Motor Behavior of Parkinson's Disease Animal Model by Nurr1-Transfected Human Embryonic Stem Cells.
한국수정란이식학회 심포지움
2003 .01
-
DEVELOPMENT OF GRAFTING ROBOT
한국농업기계학회 International Conference
2000 .01
-
Proteomic Analysis of Human Embryonic Stem Cells
한국수정란이식학회 심포지움
2006 .01
-
Feeder Free 상태에서 배양된 인간 배아 줄기세포를 이용한 중간엽 줄기세포 분화 및 단백체학을 이용한 골수 유래 중간엽 줄기세포와의 비교
한국동물번식학회지
2010 .01
-
Effect of Parthenogenetic Mouse Embryonic Stem Cell (PmES) in the Mouse Model of Huntington′s Disease
한국동물번식학회 학술대회
2003 .01
-
Effect of Extrinsic Factors on Differentiated Cardiomyocyte-like Cells from Human Embryonic Stem Cells
한국동물번식학회지
2009 .01
-
인간 배아 줄기세포와 암 세포에서의 C6orf62의 발현 패턴
한국동물번식학회지
2010 .01
-
Effect of Inhibitor of Glycogen Synthase Kinase 3 on Self-Renewal of Human Embryonic Stem Cells
한국동물번식학회지
2005 .01
-
Grafting Methods for Producing Grafted Vegetable Seedlings in Korea
한국원예학회 기타 간행물
2006 .08
-
Effects of the Age of Scions and Rootstocks and Grafting Positions on the Graft-Take and Subsequent Growth of Grafted Pepper Transplants
한국원예학회 기타 간행물
2006 .08
-
Optimization of Human Embryonic Stem Cells into Differentiation of Dopaminergic Neurons in Vitro: II. Genetically Modified Human Embryonic Stem Cells Treated with RA/AA or b-FGF
한국동물번식학회 학술대회
2003 .01
-
Derivation of Oocyte-like Structure from Mouse Embryonic Stem Cells
한국수정란이식학회 심포지움
2005 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0