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Design, Synthesis and Biological Activities of Novel Vanilloid Receptor Antagonists
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논문 기본 정보

Type
Proceeding
Author
Lee, Bo-Young (Pacific R&#65286) Suh, Young-Ger (D Center) Lee, Yong-Sil (College of Pharmacy, Seoul National Universit) Min, Kyung-Hoon (Pacific R&#65286) Kim, Jin-Kwan (D Center) Seung, Ho-Sun (Pacific R&#65286) Park, Young-Ho (D Center)
Journal
대한약학회 대한약학회 학술대회 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
Published
2003.1
Pages
2,441 - 2,441 (1page)

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Design, Synthesis and Biological Activities of Novel Vanilloid Receptor Antagonists
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Advances in understanding of pain and analgesia have been made. Over the past few years, we have designed and synthesized a series of VR agonists, based on the structures of 12-HPETE and capsaicin. the natural VR agonist. But for the development of analgesic drugs, these synthetic VR agonists had problems like burning sensation. hypothermia. etc. So our recent studoes have focused on designs and syntheses of VR antagonists based on the structure of capsaicin(natural VR agonist), and capsazepine(synthetic VR antagonist). (omitted)

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