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논문 기본 정보

자료유형
학술저널
저자정보
김금원 (포항 선린병원 진단방사선과) 임명아 (포항 선린병원 진단방사선) 손미연 (포항 선린병원 진단방사선) 이승훈 (포항 선린병원 진단방사선) 하덕기 (포항 선린병원 진단방사선) 권귀련 (포항 선린병원 진단방사선) 김성수 (포항 선린병원 진단방사선) 홍영습 (포항 선린병원 산업의학) 이용희 (포항 선린병원 신경과)
저널정보
대한영상의학회 대한방사선의학회지 대한방사선의학회지 제38권 제3호
발행연도
1998.1
수록면
403 - 410 (8page)

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Purpose : To evaluate the clinical and brain MRI findings of welders and to determine the utility of MRI inthe assessment of occupational manganese exposure Materials and Methods : Eighteen welders, working non-regularly,and three of their wives were examined. Clinical, neurologic and brain MRI findings were retrospectively analyzed.Blood manganese(Mn), urine Mn, serum iron(Fe) and blood cadmium (Cd) were measured. The mean period of exposurewas 16(7-32) years. High signal intensity of the globus pallidus(GP). as seem on T1-Weighted images(T1WI), wasgraded as follows : Grade 1, when its signal intensity (SI) was slighty higher than that of frontal subcorticalwhite matter; Grade 3, when the SI of GP was as high as that of subcutaneous fat ; and grade 2 for intermediatecases. We calculated the pallidal index (SI of GP/SI of frontal subcortical white matter) and correlated this withblood and urine Mn levels. Results : All welders complained of fatigue, headache, anorexia, and decreased libido.The palmomental reflex was positive in five(28%), Myerson's sign in four(22%), and intention tremor in three(17%).Mean blood Mn was 5.18(range, 1.77-9.34)$\mu\textrm{g}$/㎗, mean urine Mn was 5.84(range, 1.07-22/$\mu\textrm{g}$/$\ell$, serum Fe was elevatedin one welder, and serum Cd in two. T1WI of brain MRI revealed high signal intensities in the globus pallidus, theputamen, the substantia nigra, the tectum, the caudate nucleus, the subthalamic nucleus, the hypothlamus along theextrapyramidal tract, and the pituitary gland. T2WI of brain MRI revealed no significant signal change. PI and GPgrading showed good correlation($ extsc{k}$=0.60). Blood Mn correlated closely with the pallidal index(Rs=0.48, P=0.046),but there was no correlation between urine Mn and the pallidal index(Rs=0.1>0.05). Conclusion : T1WI of brain MRIin welders showed high signal intensities in the globus pallidus, the putamen, the tectum, the caudate nucleus,the subthalamic nucleus, the hypothalamus and the pituitary gland. These intensities correlated closely with bloodMn levels, suggesting their potential role in estimating the accumulation of Mn in the brain.

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