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논문 기본 정보

자료유형
학술저널
저자정보
김기수 (광주 기독병원 정형외과) 최용수 (광주 기독병원 정형외과) 염경성 (광주 기독병원 정형외과) 손경선 (광주 기독병원 정형외과) 이재혁 (전남대학교 의과대학 병리학교실)
저널정보
대한골관절종양학회 대한골관절종양학회지 대한골관절종양학회지 제5권 제4호
발행연도
1999.1
수록면
221 - 228 (8page)

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The purpose of this study was to verify the importance of apoptosis in genesis of osteosarcoma and whether apoptosis may play an important role as a predictive factor for the response to chemotherapy. Of the patients who were diagnosed osteosarcoma between January 1995 and June 1999, ten patients were selected. All specimens were obtained before and after preoperative chemotherapy and examined for the occurrence of apoptosis. Apoptosis was investigated by in situ end-labeling technique on paraffin-embedded sections and apoptotic indices were calculated before and after chemotherapy. The ages of ten patients ranged from 15 to 59 with equal sex ratio. All patients completed the planned pre-operative chemotherapy. Apoptosis occurs in osteosarcoma and apoptotic indices are increased after chemotherapy. Mean apoptotic index (AI) before and after chemotherapy were 17.2 (range 6-28.9) and 26.3 (9.6-46.2), respectively. Apoptotic cells were usually present around the necrotic area. The AI was increased as the progression of stage and in responder group more than in non-responder. Apoptosis is induced by pre-operative chemotherapy and the response is variable. Changes in AI levels before and after chemotherapy may possibly predict an individual patient's overall response.

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