지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The cAMP-dependent protein kinase(PKA) is an intracellular enzyme with serine-threonine kinase activity that plays a key role in cell growth, differentiation, and apoptosis in eukaryotes. In order to understand the PKA signal transduction pathway regulating cell life cycle and identify its role, we focused on the characterization of up-/down-regulated genes by PKA using the differential display polymerase chain reaction. Seven differentially expressed sequence tags(DEST) have been obtained. Among these DESTs, 2 DESTs were homologous to the sequence of genes from BLAST search result. KC1-5 DEST that was up-regulated in A123.7 cells was highly corresponded to mouse apoptosis-related gene(MA-3) or mouse mRNA for topoisomerase inhibitor suppressed(TIS). MA-3 was induced in various types of apoptosis, specially in NGF-deprived apoptotic PC12 cells. TIS was down-regulated in the RVC lymphoma cells incubated with topoisomerase inhibitor that induces DNA strand breakages. PG1-1 DEST that was highly expressed in PC12 cells was corresponded to transposon Tn10 3'-end. Tnansposon Tn10 was up-regulated in differentiated myeloblastic ML-1 cells by 12-O-tetradecanoylphorbol-13-acetate. This study illuminates that MA-3/TIS was down-regulated by PKA activity, and transposon Tn10 was up-regulated by it.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Microarray Analysis of Gene Expression Alteration in Human Middle Ear Epithelial Cells Induced by Asian Sand Dust
Clinical and Experimental Otorhinolaryngology
2015 .01
-
鮮地黃이 PC12 세포 및 뇌해마 신경세포 손상에 미치는 영향
동의생리병리학회지
2007 .12
-
탁리소독음(托裏消毒飮)의 PC-3 세포에 대한 세포고사 유도 효과 및 기전 연구
동의생리병리학회지
2006 .01
-
Cyclic AMP-PKA System이 억제성 및 흥분성 한약재에 의해 유발된 이온전류에 미치는 영향
Korean Journal of Acupuncture
2001 .01
-
Functional Gene Analysis to Identify Potential Markers Induced by Benzene in Two Different Cell Lines, HepG2 and HL-60
Molecular & cellular toxicology
2008 .01
-
Comparison of As2O3 and As4O6 in the Detection of SiHa Cervical Cancer Cell Growth Inhibition Pathway
Cancer Research and Treatment
2004 .01
-
The effects of HDAC inhibitors on proliferation and apoptosis in PC3 cells
환경독성보건학회 심포지엄 및 학술대회
2004 .05
-
Biological Effects of Smoking-induced Environmental Toxicity
Molecular & cellular toxicology
2006 .01
-
Validation of Kinetic Method for the PKA Assay in Plasma-Derived Products
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2005 .01
-
Expression of Hepatitis B Virus X Protein in Hepatocytes Suppresses CD8+ T Cell Activity
Immune Network
2010 .08
-
Cell Cycle, Cell Death and Apoptosis
대한핵의학회 연수교육
2002 .01
-
Differences in Their Proliferation and Differentiation between B-1 and B-2 Cell
Immune Network
2006 .03
-
β- Catenin Regulates the Expression of cAMP Response Element-Binding Protein 1 in Squamous Cell Carcinoma Cells
Annals of Dermatology
2018 .01
-
p53 and Cell Cycle-Regulated Protein Expression in Small Intestinal Cells after Fast Neutron Irradiation in Mice
한국수의병리학회 학술발표논문집
2004 .01
-
Molecular Mechanism of NO-induced Cell Death of PC12 Cells by $IFN{\gamma}\;and\;TNF{\alpha}$
Molecular & cellular toxicology
2005 .01
-
Identification of Differentially Expressed Genes in Human Mesenchymal Stem Cell-Derived Neurons
Toxicological Research
2010 .03
-
pc12 세포에서 신경전달물질 방출을 저해하는 s9940 물질 물질의 탐색 ( screening of s9940 as an inhibitor of neurotransmitter release from pc12 cells )
한국독성학회지
1998 .09
-
감마방사선에 의한 암세포의 세포손상에 관한 연구
대한방사선협회지
2004 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0