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자료유형
학술저널
저자정보
Chae, Han-Jung (Department of Dental Pharmacology, School of Dentistry, Wonkwang University) Kang, Jang-Sook (Department of Dental Pharmacology, School of Dentistry, Wonkwang University) Kim, Jong-Hwan (Department of Gynecology, School of Oriental Medicine, Wonkwang University) Kim, Chul-Won (Department of Gynecology, School of Oriental Medicine, Wonkwang University) Yoo, Sim-Keun (Department of Gynecology, School of Oriental Medicine, Wonkwang University) Choi, Bom (Department of Oriental Pharmacy, School of Pharmacy, Wonkwang University) Kim, Hyung-Min (Department of Oriental Pharmacy, School of Pharmacy, Wonkwang University) Shin, Tae-Yong (College of Pharmacy, Woosuk University) Kim, Hyung-Ryong (Department of Dental Pharmacology, School of Dentistry, Wonkwang University)
저널정보
경희한의학연구센터 International journal of oriental medicine : OM International journal of oriental medicine : OM 제1권 제1호
발행연도
2000.1
수록면
97 - 106 (10page)

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The preventive effect of herbal formulation, ‘Dae-Bo-Won-Chun’(DBWC), on the progress of bone loss induced by ovariectomy (OVX) was studied in rats. From light microseopic analyses, a porous or erosive appearances were observed on the surface of trabecular bone of tibia in ovariectomized rats. Whereas those of the same bone in sham rats were composed of fine particles. The trabecular bone area and trabecular thickness in ovariectomized rats decreased by 50% from those in sham-operated rats, these decreases were completely inhibited by administration of DBWC at concentration of 10mg/kg per day for 7 weeks. The mechanical strength in femur neck was decreased by ovariectomy, and this was significantly suppressed by the administration of DBWC. Serum phosphorus, alkaline phosphatase, and thyroxine levels in ovariectomized rats were increased compared to those in sham-operated rats, and increases were completely inhibited by the administration of DBWC. These results strongly suggest that DBWC is effective in preventing the development of bone loss induced by ovariectomy in rats.

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