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자료유형
학술저널
저자정보
Lim, Seok-Tae (Department of Nuclear Medicine, Chonbuk National University Medical School) Park, Soon-Ah (Department of Nuclear Medicine, Chonbuk National University Medical School) Sohn, Myung-Hee (Department of Nuclear Medicine, Chonbuk National University Medical School) Yim, Chang-Yeol (Department of Internal Medicine, Chonbuk National University Medical School)
저널정보
대한핵의학회 대한핵의학회지 대한핵의학회지 제34권 제5호
발행연도
2000.1
수록면
433 - 435 (3page)

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A 6000-year-old male with carcinoma of the prostate and cerebral infarction underwent a Tc-99m MDP bone scintigraphy for the evaluation of skeletal metastases. Bone scintigraphy (Fig. 1) showed multiple areas of increased uptake of Tc-99m MDP in the skull, spine, and ribs representing skeletal metastases. Two different patterns of uptake occurred in the skull region (Fig. 1A-C); one represents bony metastasis and the ether represents cerebral infarction. The shape, size, location, intensity, and border of the increased uptake differed between the two lesions. An oval-shaped pattern with smaller size, greater intensity and more sharply defined border in the frontal region was consistent with bony metastasis. A rectangular-shaped pattern with larger size, lesser intensity and relatively indistinct border in the temporo-parieto-occipital region was consistent with cerebral infarction. Increased uptake of bone-seeking radiotracers in cerebral infarction has been reported previously.$^{1-4)}$ A suggested mechanism by which bone-seeking radiotracers accumulate in the necrotizing cerebral tissue is an alteration of the blood-brain barrier induced during cerebral infarction, which results in entry of the radiotracers into the extracellular space of the brain.$^{4)}$ Brain CT (Fig. 2) performed 7 days before and one month after the bone scintigraphy revealed lesions on the right temporo-parieto-occipital region consistent with acute hemorrhagic and chronic cerebral infarction, respectively.

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