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The Action of ATP on Phospholipase $A_2$Activation in C6 Cells
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C6세포에서 phospholipase $A_2$활성에 대한 ATP의 작용

논문 기본 정보

Type
Academic journal
Author
심상수 (중앙대학교 약학대학 병태생리학교실) 김명준 (가톨릭대학교 의과대학 생리학교실) 윤신희 (가톨릭대학교 의과대학 생리학교실) 김창종 (중앙대학교 약학대학 병태생리학교실) 조양혁 (가톨릭대학교 의과대학 생리학교실)
Journal
대한약학회 약학회지 약학회지 제45권 제4호
Published
2001.1
Pages
413 - 418 (6page)

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The Action of ATP on Phospholipase $A_2$Activation in C6 Cells
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To investigate action of ATP on ischemia-induced brain injury, we measured phospholipase $A_2$activity and nitric oxide (NO) production in C6 cells. ATP alone did not have any influence on phospholipase $A_2$activity but increased NO production. Glutamate (1 mM) significantly increased phospholipase $A_2$activity whereas did not increased NO production. ATP significantly inhibited phospholipase $A_2$activation induced by 0.1 $\mu$M A23187, 1 mM glutamate and 1 mM $H_2O$$_2$, but did not inhibited 1 $\mu$M PMA-induced phospholipase $A_2$activation. From the above results, it is suggested that the action of ATP in C6 cells has dual actions, such as the inhibition of agonist-induced phospholipase $A_2$activation and the increase of NO production.
#C6 cells #ATP #phospholipase $A_2$ #nitric oxide

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