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논문 기본 정보

자료유형
학술저널
저자정보
홍성우 (전북대학교 치과대학 구강악안면방사선학교실) 최은숙 (전북대학교 치과대학 구강악안면방사선학교실) 고광준 (전북대학교 치과대학 구강악안면방사선학교실)
저널정보
대한영상치의학회 치과방사선 치과방사선 제28권 제1호
발행연도
1998.1
수록면
271 - 283 (13page)

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The purpose of this study was to aid in the prediction of tumor cell tolerance to radiotherapy and/or chemotherapy. For this study, cell surviving curves were obtained for human squamous cell carcinoma KB cell line after radiation exposure and/or administration of antitumor drugs. 2, 4, 6, 8, 10Gy were irradiated at a dose rate of 210cGy/min using <SUP>60</SUP>Co Irradiator ALDORADO 8. After irradiation, KB cell lines (3&times;104cells/ml) were exposed to 2&#13197;/ml of bleomycin or cisplatin for 1 hour. The viable cells were determined by MTT assay for each radiation dose and/or each drug at the 4th day. And they were compared to control values. The obtained results were as follows : 1. The slope of the surviving curve after irradiation of 2, 4, 6, 8, 10Gy on KB cell line was relatively steep. 2. There was no significant difference between the cytotoxicity of bleomycin compared to control group. But, there was significant difference between the cytotoxicity of cisplatin compared to control group. And the cytotoxicity of cisplatin was greater than that of bleomycin on KB cell line. 3. There were significant differences of surviving fractions after irradiation of 2Gy and 10Gy with 2&#13197;/ml of bleomycin compared with the groups of irradiation only on KB cell line. 4. There were significant differences of surviving fractions after irradiation of 2, 4, 6, 8, 10Gy with 2&#13197;/ml of cisplatin compared with the groups of irradiation only on KB cell line. 5. There was significant difference of surviving fraction between groups after irradiation of 10Gy with 2&#13197;/ml of bleomycin and cisplatin.

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