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논문 기본 정보

자료유형
학술저널
저자정보
유형식 (연세대학교 의과대학 방사선과학교실) 서정호 (연세대학교 의과대학 방사선과학교실) 이종태 (연세대학교 의과대학 방사선과학교실) 김동익 (연세대학교 의과대학 방사선과학교실) 박창윤 (연세대학교 의과대학 방사선과학교실) 김병수 (연세암센타) 박찬희 (미국 Thomas Jefferson 의과대학 핵의학교실)
저널정보
대한핵의학회 대한핵의학회지 대한핵의학회지 제20권 제2호
발행연도
1986.1
수록면
61 - 71 (11page)

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An iodized oil such as Ethiodol or Lipiodol was selectively retained in the tumor vessels of the large hepatomas as well as in the small daughter hepatomas for long periods following the intra-arterial hepatic injection of such contrast material. The specific aim of the study is to deliver a high internal radiation dose to hepatocellular carcinoma (HCC) in an attempt to control the disease. We were able to replace a small fraction of the stable iodine (I-127) of the 37% iodine in Lipiodol by the $I^{-131}$ with 100% exchange efficiency. $I^{-131}$ labeled Lipiodol was injected through the super-selected tumor feeding artery under superselection or into the proper hepatic arterial level of patients who have malignant hepatomas confirmed by aspiration cytology serum AFP and various imaging modalities. Clinical traial was performed on 43 cases during recent 6 months and follow-up observation was carried out. No severe complications or other adverse reactions were encountered until nowdays. $I^{-131}-Lipiodol$ was stable in vivo and no significant activity was noted in the thyroid, stomach, blood and urine after the injection. Only small fraction of radioisotope activity was noticed in the both side of lungs. Tumor to normal liver radio was very high. Therefore, $I^{-131}-Lipiodol$ (or P-32-Lipiodol) will be effective delivering high internal radiation dose to the tumor while delivering small radiation doses to normal tissues. Labeling, tumor dose calculation and preliminary findings will be presented.

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