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논문 기본 정보

자료유형
학술저널
저자정보
양승오 (동아대학교 의과대학 진단방사선과학교실) 강흥식 (서울대학교 의과대학 진단방사선과학교실) 장기현 (서울대학교 의과대학 진단방사선과학교실) 이명철 (서울대학교 의과대학 내과학교실) 구경회 (서울대학교 의과대학 정형외과학교실) 성상철 (서울대학교 의과대학 정형외과학교실) 박인애 (영등포병원 해부병리과)
저널정보
대한핵의학회 대한핵의학회지 대한핵의학회지 제24권 제1호
발행연도
1990.1
수록면
124 - 132 (9page)

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It has been reported that hematoma is one of the most crucial factors in fracture healing since callus formation is disturbed by washing out the hematoma near a fracture site. However, it is not clear why the hamatoma is important and how it plays a role during the fracture healing. In order to investigate the role of hematoma in the process of fracture healing, the osteogenic potential by subperiosteal transplantation have been studied. Experimental fractures by operation were made at the mid-shaft of the tibia in New Zealand white rabbits. Removal of hematoma at the fracture site was done after 2 and 3 days from experimental fracture, and the removed hematoma was transplanted into the subperiosteal area at the mid-shaft of the ulna of each rabbit. As control groups, we have performed 3 different procedures 1) the hematoma was transplanted into the muscular layers at the thigh and forearm; 2) autologous blood clots were transplanted into the subperiosteal area of the ulna; and 3) sham operation without a transplantation into the subperiosteal area. After transplantation, serial bone scintigraphy and simple radiography were performed at 4 days, 1 week, and 2 weeks to detect an abnormality. The results of bone scintigraphy were positive in 5 of 6 experimental group. However, all in three control groups were negative. Histological observation of the positive bone revealed new bone formation with trabeculation. These results suggest the hematoma in fracture site has osteogenic potential in the subperiosteal area which can be demonstrable by bone scintigraphy and histologic findings. Therefore, it is considered that hematoma of the fracture site plays an important role in the process of fracture healing. Further biochemical investigation using various experimental models is mandatory to apply this preliminary result to the treatment of clinical delayed union or nonunion.

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