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Ultrastructural Changes of Fat-storing Cells in Experimental Hepatic Fibrosis
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실험적 간섬유화에서 Fat-storing Cell의 미세구조의 변화에 대한 연구

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Type
Academic journal
Author
Kim, Mi-Jin (영남대학교 의과대학 해부병리학교실) Choi, Won-Hee (영남대학교 의과대학 해부병리학교실) Lee, Tae-Sook (영남대학교 의과대학 해부병리학교실)
Journal
영남대학교 의과대학 영남의대학술지 영남의대학술지 제9권 제2호
Published
1992.1
Pages
224 - 238 (15page)

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Ultrastructural Changes of Fat-storing Cells in Experimental Hepatic Fibrosis
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Hepatic fibrosis was induced in Sprague-Dawley rats to evaluate the ultrastructural changes of fat-storing cells(Ito cells). For experimental induction of liver fibrosis, the rats were administered intraperitoneally with 0.5ml of 50% $Ccl_4$ solution per Kg body weight, twice weekly for 12 weeks. The rats were sacrified every week. The liver tissues were examined under light and eletron microscopes. And the immunohistochemical study of desmin was also performed. The results were summarized as follows : Light microscopic findings : The cellular infiltrations with inflammatory cells and Kupffer cells developed from 1 week after $Ccl_4$ injection, and were the most severe in 4 weeks. The strong immunoreactivity for desmin was also evident in 4 weeks. The centrilobular necrosis and fibrosis developed from 2 weeks after injection, and the necrosis persisted until 8 weeks. The progress of fibrosis was accompanied by decreases in cellular infiltration and reactivity for desmin, and increased gradual nodular formation was also observed. The cirrhosis was developed after 10 weeks. Electron microscopic findings : An increase in number of fat-storing cells was observed from 1 week after injection. Transitional cells characterized by a depletion of lipid droplets and a hypertrophy of the rER appeared after 2 weeks. The number of transitional cells with abundant collagen fibers in the extracellular spaces increased in 4 weeks. With progression of fibrosis the number of fat-storing cells decreased and proliferating fibroblasts with dilated rER were observed. According to these results it was revealed that there was an apparent transition from fat-storing cells to transitional cells and to fibroblasts. These cells had a few similar characteristics and may belong to the same cell population. Thus it was suggested that fat-storing cells might play an important role in hepatic fibrosis.

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