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The purpose of this research was to investigate effects of baicalin on the differentiation of preadipocytes, 3T3-L1, and to characterize the action of baicalin that affect the responses of 3T3-L1 cells during differentiation. In various culture conditions, effects of baicalin and adrenoreceptor agonists such as phenylephrine(PE) and isoproterenol(IPR) on cell differentiation were examined. Also, effects of the drugs on differentiation, triglyceride(TG) contents, expression of insulin receptor, cAMP contents, the cytosolic $Ca^{2+}$ levels, and amount of calmodulin(CaM) were examined. The results suggest that baicalin has adrenergic receptor blocking activity during the process of differentiation of 3T3-L1 cells and that in the early stage of the adipose conversion, the effect of baicalin on the adipocyte differentiation is mediated by the regulation of insulin receptor expression, but by alterations of the cAMP and the calcium metabolism in the late stage. These results also suggest that the action of baicalin may be significant in the lipid metabolism, lipogenic and lipolytic pathways, of adipose cells.
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Baicalin이 조골세포의 생성 및 활성에 미치는 영향
Journal of Oral Medicine and Pain
2008 .06
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2012 .01
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Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
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Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2014 .01
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Baicalin Induces Apoptosis in Leukemia HL-60/ADR Cells via Possible Down-regulation of the PI3K/Akt Signaling Pathway
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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Baicalin을 처리한 HL-60 백혈병 세포주에서 대규모 유전자 분석 발현 연구
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2004 .10
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The Inhibitory Effect of Baicalin on the Short-Term Food Intake in C57BL/6J Mice
Biomolecules & Therapeutics(구 응용약물학회지)
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The Role of Intestinal Microflora in Anti-Inflammatory Effect of Baicalin in Mice
Biomolecules & Therapeutics(구 응용약물학회지)
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Metabolism of glycyrrhizin and baicalin by human intestinal bacteria
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
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면역결핍바이러스 인테그라제 억제제로서 Baicalein과 Baicalin
약학회지
2003 .01
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The Molecular Mechanism of Baicalin on RANKL-induced Osteoclastogenesis in RAW264.7 Cells
International Journal of Oral Biology
2013 .01
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Studies on Gene Expression of baicalin treated in HL-60 cell line using High-throughput Gene Expression Analysis Techniques
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흰쥐의 일차배양 간세포에서 Glycyrrhizin 및 Baicalin의 간 보호 활성 평가
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Effects of Baicalin on the acute liver and kidney injury induced by hepatic ischemia/reperfusion in rats
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2013 .02
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Baicalin attenuates lipopolysaccharide-induced neuroinflammation in cerebral cortex of mice via inhibiting NF-κB activation
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Effects of Baicalin on the differentiation and activity of preosteoclasts
International Journal of Oral Biology
2009 .01
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A Study on the Transformation of Baicalin or Antibacterial, Antitumor Effect of the Active Ingredients in Scutellariae Radix
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