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논문 기본 정보

자료유형
학술저널
저자정보
Woo, Eun-Rhan (Division Of Applied Science, Korea Institute of Science and Technology) Kim, Hyoung-Ja (Division Of Applied Science, Korea Institute of Science and Technology) Jong, Hwan-Kwak (Division Of Applied Science, Korea Institute of Science and Technology) Lim, Young-Kwern (Division Of Applied Science, Korea Institute of Science and Technology) Park, Seong-Kyu (Division Of Applied Science, Korea Institute of Science and Technology) Kim, Hae-Soo (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) Lee, Chong-Kyo (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) Park, Hokoon (Division Of Applied Science, Korea Institute of Science and Technology)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제20권 제1호
발행연도
1997.1
수록면
58 - 67 (10page)

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In order to find antiviral compounds against Herpes simplex virus type I (HSV-1) and II (HSV2) from natural products, a convenient virus-induced cytopathic effect (CPE) inhibition assay was introduced. More than 300 fractions were prepared by solvent fractionation from sixty collected plants or purchased herbal medicines, and their anti-herpetic activities were evaluated. Among them, several medicinal plants showed potent anti-herpetic activity. Selective indexes (SI) of the EtOAc extract of Caraganae Radix (Caragana sinica) against HSV-1 and HSV-2 were more than 8.06 and 24.79, SI of the MeOH extract of Acer okamotoanum leaves were 3.92 and 3.51, SI of the $CH_{2}Cl_{2}$ extract of Veratri Rhizoma et Radix (Veratrum patulum) were 5.49 and 1.31 and SI of the MeOH extract of aerial part of Osmundae Rhizoma (Osmunda japonica) were more than 3.45 and 1.25, respectively.

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