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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 35 - 47 (13page)
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초록· 키워드
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2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) are well known as the most toxic environmental compound in these days. Many researches are reported that dioxin produces multiple toxic effects, such as endocrine toxicity, reproductive toxicity, immunotoxicity and cancer. In this study, we carried to discover novel evidence for previously unknown gene expression patterns in human exposed to dioxin by using radioactive cDNA microarray. 548 workers who were divided into experimental and control groups according to their urinary Naphthol levels were enrolled in our study. Blood mRNA in human was isolated, and the gene expression profiles were analyzed by cDNA microarray. Gene expression analysis identified 52 genes which exhibited a significant change. In our study, most notably, genes involved in cell cycle, cell proliferation, signal transduction and apoptosis in human exposed to dioxin, such as CCND3, TSHR, and EFRN5, were up-regulated. In the current study, we observed gene expression of people that are exposed to dioxin using radioactive cDNA microarray. Through these results, we suggest when objects are exposed to toxic compounds, such as dioxin, the radioactive cDNA microarray may be using in sensitively detecting of cancerous change.
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신경정신 의학분야의 방사성동위원소 표지 cDNA 마이크로어레이
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Microarray Applications in Cancer Research
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Biomedical research에서의 cDNA Microarray의 적용
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O1igonucleotide Microarray와 cDNA Microarray를 이용한 위암조직의 대단위 유전자 발현 비교
약학회지
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cDNA Microarray Analysis of the Gene Expression after Ad5CMV-p16INK4a Gene Transfer in the Non-Small Cell Lung Cancer Cells
대한약학회 학술대회
2001 .01
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Risk Assessment and Communication of Dioxin Exposure in Korea : Serum Dioxin Levels and Perceived Risks
환경독성보건학회 심포지엄 및 학술대회
2006 .05
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대표적인 열분해가스화 응용시설의 공정별 다이옥신 배출거동에 관한 연구
환경위생공학
2007 .03
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