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자료유형
학술저널
저자정보
Hong, Jin-Tae (National Institute of Toxicological Research, Korea Food and Durg Administration 5) Ryu, Seung-Rel (National Institute of Toxicological Research, Korea Food and Drug Administration 5) Kim, Hye-Jin (National Institute of Toxicological Research, Korea Food and Drug Administration 5) Lee, Sun-Hee (National Institute of Toxicological Research, Korea Food and Drug Administration 5) Lee, Byung-Moo (Division of Toxicology, College of Pharmacy, SengKyunKwan University) Kim, Pu-Young (National Institute of Toxicological Research, Korea Food and Drug Administration 5)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제23권 제4호
발행연도
2000.1
수록면
413 - 417 (5page)

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The effect of ischemia/reperfusion-induced neuronal damage on the memory impairment were investigated using active avoidance and Morris water maze tasks in Wistar rats. Focal ischemia was induced by 1 h occlusion of the right middle cerebral artery (MCA) of Wistar male rats. Reperfusion was induced by releasing the occlusion and restoring the blood circulation for 24 h. The acquisition and preservation memory tested by active avoidance showed a significant difference between the sham and ischemia/reperfusion group. The water maze acquisition performance was also significant difference between sham and ischemia/repefusion groups in both latency and moving distance. The infarction volume was increased by the ischemia/reperfusion. Furthermore, the cresyl violet staining of the ischemia/reperfusion brain showed severe neuronal damage (pyramidal cell loss) in the cortex in addition to the striatum lesion of brain. This study shows that pyramidal cell damage in the cortex lesion may be partially related to memorial disturbance in the ischemia/reperfusion brain injury.

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