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자료유형
학술저널
저자정보
Choi, Hee-Jung (Department of Pharmacology, College of Pharmacy, Chung Ang University) Je, Hyun-Dong (Department of Pharmacology, College of Pharmacy, Chung Ang University) Jeong, Ji-Hoon (Department of Pharmacology, College of Pharmacy, Chung Ang University) Min, Young-Sil (Department of Pharmacology, College of Pharmacy, Chung Ang University) Choi, Tae-Sik (Department of Pharmacology, College of Pharmacy, Chung Ang University) Park, Joon-Hong (Department of Pharmacology, College of Pharmacy, Chung Ang University) Shin, Chang-Yell (Department of Pharmacology, College of Pharmacy, Chung Ang University) Sohn, Uy-Dong (Department of Pharmacology, College of Pharmacy, Chung Ang University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제26권 제3호
발행연도
2003.1
수록면
237 - 243 (7page)

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We investigated the role of ascorbic acid on the redox status in streptozotocin-induced diabetic rats. In the plasma of diabetic rats, the ratio of reduced/total ascorbic acid was significantly decreased as compared with normal control. Ascorbic acid supplementation increased the reduced and total ascorbic acid contents as compared with diabetic control. In the rutintreatment group, reduced and total contents of ascorbic acid were significantly decreased, however, the ratio of reduced/total contents of ascorbic acid had no difference as compared with diabetic rats. In the insulin-treatment group, this ratio is not significantly different as compared with diabetic control. However, in the insulin plus ascorbic acid treatment group, reduced form and the ratio of reduced/total ascorbic acid were significantly increased as compared with diabetic control. In addition, we measured the contents of malondialdehyde (MDA) in the plasma of diabetic rats. The contents of MDA was increased as compared with normal control, however, in insulin-treatment group, the contents of MDA was decreased as compared with diabetic rats. Ascorbic acid had no effects on the increases of MDA in diabetic rats. In conclusion, plasma ascorbic acid level and its reduced/total ratio reflects the status of the oxidative stress in the diabetic rats. Supplement of ascorbic acid did not correct the ratio of the reduced/total ascorbic acid. However, supplement of insulin and ascorbic acid corrected the ratio of reduced/total ascorbic acid.

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