지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제28권 제7호
- 발행연도
- 2005.1
- 수록면
- 756 - 760 (5page)
이용수
초록· 키워드
오류제보하기
Polyene macrolide amphotericin B (AmB) is the drug of choice for the treatment of disseminated fungal infections. However, because of its pronounced side effects, the drug has limited applicability. There are few interesting reports, which state that co-administration of the drug with homo-peptide of polyaspartic acid reduces the side effects of the drug. In our present study, an approach has been made to systematically synthesize low molecular weight heteropeptides consisting of L-aspartic acid and its derivative. It was hypothesized that such heteropeptides will reduce the toxic side effects of the drug by facile hydrophobic binding between the polymer and the drug. We have employed the strategy of solid phase peptide synthesis (SPPS) to synthesize low molecular weight hetero-peptides by using L-aspartic acid and benzyl-L-aspartic acid to induce the hydrophobic binding between the peptide and the drug. In future, the proposed methodology can be employed to tailor other polypeptides substituted with benzyl groups to reduce the nephrotoxicity of AmB.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Synthesis of Peptides of L-Aspartic Acid Derivatives by Solid Phase Peptide Synthesis Methodology
대한약학회 학술대회
2004 .01
-
In vivo evaluation of peptide based imaging probe for drug efficacy monitoring
한국실험동물학회 학술발표대회 논문집
2016 .08
-
일산화탄소 중독이 뇌내 아미노산 신경전달물질 함량변화에 미치는 영향
약학회지
1990 .01
-
Recent Trends in Cyclic Peptides as Therapeutic Agents and Biochemical Tools
Biomolecules & Therapeutics(구 응용약물학회지)
2020 .01
-
Bioactive Conformation of Peptides for Drug Design
대한약학회 학술대회
2000 .01
-
Cyclic Peptides as Therapeutic Agents and Biochemical Tools
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
Physical stability of arginine-glycine-aspartic acid peptide coated on anodized implants after installation
The Journal of Advanced of Prosthodontics
2013 .01
-
Site-specific PEGylation of Peptide Drugs
대한약학회 학술대회
2002 .01
-
Designing a drug delivery system for improved tumor treatment and targeting by functionalization of a cell-penetrating peptide
Journal of Pharmaceutical Investigation
2019 .01
-
당뇨병에서 24시간 뇨중 C-peptide에 관한 연구
대한핵의학회 학술대회
1985 .01
-
Kojic Acid Peptide: A New Compound with Anti-Tyrosinase Potential
Annals of Dermatology
2016 .01
-
Molecular Design of New Drug
대한임상약리학회 학술대회
1996 .01
-
Levels of Viral Glycoprotein Provide a Measure of Modulated Chemotherapeutic Effect
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1999 .01
-
Reactivity and Suitability of t-Boc-protected Thiophosphotyrosine Intermediate Analogs for the Solid or Solution Phase Peptide Synthesis
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1998 .01
-
한국 초.중.고.대학생들에서 약물정보습득의 방법 및 약물오남용의 위험성에 대한 평가
약학회지
2013 .01
-
The Effects of Soybean Peptide Intake on Index of Muscle Damage and Hormone Concentration in Taekwondo Player
대한의생명과학회지
2011 .09
-
High Throughput Systems for Peptide Synthesis & Protein Identification
대한약학회 학술대회
2005 .01
-
Identification of a novel peptide that selectively binds to Kidney Injury Molecule-1 (KIM-1) by phage displayed peptide library
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Identification of kidney-specific binding peptide from phage displayed peptide library: Involvement of cisplatin-induced acute kidney injury molecule-1 (KIM-1)
한국실험동물학회 학술발표대회 논문집
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0