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논문 기본 정보

자료유형
학술저널
저자정보
Park, Jeong-Sook (College of Pharmacy, Chungbuk National University) Hwang, Seock-Yeon (Department of Clinical Laboratory Science, Juseong College) Lee, Won-Suk (College of Pharmacy, Chungbuk National University) Yu, Kee-Won (CBN Biotech Co. Ltd.) Paek, Kee-Yoeup (CBN Biotech Co. Ltd.) Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University) Han, Kun (College of Pharmacy, Chungbuk National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제29권 제9호
발행연도
2006.1
수록면
800 - 807 (8page)

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This study examined the possibility of using a tissue cultured root of wild Panax ginseng (tcwPG) as a fertility agent. The effect of tcwPG on spermatogenesis was studied using male rats. The tcwPG crude powder was administered orally to 7-week-old rats over a 6-week period. The number of sperm in the testes and epididymides was significantly higher than the control. A histological examination did not reveal any morphological changes in the testes from the tcwPG powder treated rats. Moreover, there were no significant differences in the weights of the heart, spleen, liver, kidney, brain, testes and epididymides. Oligospermia was also induced by administering 2,3,7,8-tetrachlorodaibenzo-p-dioxin (TCDD) to the rats in order to estimate the feasibility of using tcwPG as treatment for infertility caused by spermatogenic disorders. After exposing the rats to TCDD, the tcwPG saponin fraction treated rats showed some improvement in the body weight, sperm number and testis morphology. It was estimated that tcwPG had feasibility as a therapeutic agent on spermatogenic disorder.

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