Antioxidant Activity of Anthraquinones and Flavonoids from Flower of Reynoutria sachalinensis

Zhang Xinfeng; Thuong Phuong Thien; Jin WenYi; Su Nguyen Duy; Sok Dai Eun; Bae KiHwan; Kang Sam Sik

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자료유형: 학술저널

저자정보: Zhang Xinfeng (College of Pharmacy, Chungnam National University) Thuong Phuong Thien (College of Pharmacy, Chungnam National University) Jin WenYi (College of Pharmacy, Chungnam National University) Su Nguyen Duy (College of Pharmacy, Chungnam National University) Sok Dai Eun (College of Pharmacy, Chungnam National University) Bae KiHwan (College of Pharmacy, Chungnam National University) Kang Sam Sik (National Products Research Institute, Seoul National University)

저널정보: 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제28권 제1호

발행연도: 2005.1

수록면: 22 - 27 (6page)

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Bioassay-guided fractionation of methanol extract of Reynoutria sachalinensis flower using DPPH assay has led to the isolation of three anthraquinones and three flavonoids. Their structures were identified as emodin (1), emodin-8-O-$\beta$-D-glucopyranoside (2), physcion-8-O-$\beta$-Dglucopyranoside (3), quercetin-3-O-$\alpha$-L-arabinofuranoside (4), quercetin-3-O-$\beta$-D-galactopyranoside (5), and quercetin-3-O-$\beta$-D-glucuronopyranoside (6) by comparing their physicochemical and spectral data with those published in literatures. All isolated compounds were evaluated for antioxidant activities with free radical 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, superoxide radical scavenging and $Cu^{2+}$-mediated low density lipoprotein (LDL) oxidation assay. The results demonstrated that three flavonoids, 4, 5, and 6 had remarkable antioxidant activities with the $IC_{50}$ values of 64.3, 54.7, and 46.2${\mu}M$ (DPPH scavenging), the $IC_{50}$ values of 6.0, 6.7, and $4.4{\mu}M$ (superoxide radical scavenging) and the $IC_{50}$ values of 3.8, 3.2, and 5.4${\mu}M$ against LDL oxidation, respectively.

#Reynoutria sachalinensis #Polygonaceae #Anthraquinones #Flavonoids #Antioxidant #DPPH #Superoxide radical #LDL oxidation

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