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논문 기본 정보

자료유형
학술저널
저자정보
Moon, Chang-Kiu (College of Pharmacy, Seoul National University) Lee, Soo-Hwan (College of Pharmacy, Seoul National University) Park, Kwang-Sik (College of Pharmacy, Seoul National University) Hwang, Gwi-Seo (College of Pharmacy, Seoul National University) Mock, Myung-Soo (College of Pharmacy, Seoul National University) Chung, Dong-Seok (College of Pharmacy, Seoul National University) Kim, Dae-Dok (College of Pharmacy, Seoul National University) Min, Seok-Ki (College of Pharmacy, Seoul National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제10권 제4호
발행연도
1987.1
수록면
223 - 227 (5page)

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The effects of butylated hydroxyanisole and butylated hydroxytoluene on the immune status in normal male were evaluated. They exhibited significant decrease in the circulating leukocyte counts. Relative spleen and thymus weights were slightly decreased, but not stratistically significant. These were, however, significant liver hypertrophies in theier exposed mice. Splenic IgM PFCs per one million cells in 1/20 LD50 BHA and BHT exposed mice were significantly reduced IgM PFCs per spleen were similar tothose of control, except in 1/20 LD50 BHA exposed mice, where they were significantly suppressed. The precise nature of the inhibition is not clear. Direct cytotoxicity is not responsible for the depressed antibody response, even following relatively high doses of them, because the changes in spleen cellularity are not significant. Both substances, however, did not show any effects on the arthus reaction and delayed hypersensitivity reaction induced by heat aggreagted bovine serum albumin, and in vivo phagocytosis of colloidal carbon. In the light of the present results, in vivo antibody response as well as in vitro, may be sensitive to BHA of the present results, in vivo antibody response as well as in vitro, amy be sensitie to BHA and BHT. Further elucidation of the precise nature of antibody suppression in their exposed mice, is warranted.

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