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논문 기본 정보

자료유형
학술저널
저자정보
Lim, Dong-Yoon (College of Pharmacy, Chosun University) Lee, Jang-Hee (College of Pharmacy, Chosun University) Kim, Won-Shik (College of Pharmacy, Chosun University) Kim, Soo-Bok (College of Pharmacy, Chosun University) Lee, Eun-Hwa (College of Pharmacy, Chosun University) Lee, Byeong-Joo (College of Medicine, Chosun University) Ko, Suk-Tai (College of Medicine, Chosun University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제14권 제1호
발행연도
1991.1
수록면
55 - 67 (13page)

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이 논문의 연구 히스토리 (9)

2004

Influence of FCCP on Catecholamine Release in the Rat Adrenal Medulla
Lim ,  Dong-Yoon ,  Jo 외 11명 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 2004.01 학술저널

2002

Inhibitory Mechanism of Bromocriptine on Catecholamine Release Evoked by Cholinergic Stimulation and Membrane Depolarization from the Rat Adrenal Medulla
Lim ,  Dong-Yoon ,  Lee 외 3명 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2002.01 학술저널
Influence of Cytisine on Catecholamine Release in Isolated Perfused Rat Adrenal Glands
Lim ,  Dong-Yoon ,  Jang 외 3명 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2002.01 학술저널
Influence of CCCP on Catecholamine Secretion from the Perfused Rat Adrenal Medulla
Lim ,  Dong-Yoon ,  Jo 외 3명 대한약학회 학술대회 2002.01 학술대회자료

2001

Influence of Cilnidipine on Catecholamine Release Evoked by Cholinergic Stimulation and Membrane Depolarization in the Perfused Rat Adrenal Gland
Lim ,  Dong-Yoon ,  Woo 외 3명 한국응용약물학회 추계학술발표논문집 2001.01 학술대회자료

2000

Influence of 5′-(N′-Ethylcarboxanlido) Adenosine on Catecholarnine Secretion Evoked by Cholinergic Stimulation and Membrane Depolarization in the Rat Adrenal Gland
Lim ,  Dong-Yoon ,  Oh 외 3명 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 2000.01 학술저널
Influence of Quinidine on Catecholamine Secretion Evoked by Cholinergic Stimulation and Membrane Depolarization from the Perfused Rat Adrenal Gland
Lim ,  Dong-Yoon ,  Jeon 외 11명 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 2000.01 학술저널

1992

Influence of TMB-8 on Secretion of Catecholamines from the Perfused Rat Adrenal Glands
Lim ,  Dong-Yoon ,  Kim 외 3명 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 1992.01 학술저널

1991

Studies on Secretion of Catecholamine Evoked by Caffeine from the Isolated Perfused Rat Adrenal Gland
Lim ,  Dong-Yoon ,  Lee 외 11명 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 1991.01 학술저널

초록· 키워드

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The influence of caffeine on secretion of catecholamines (CA) was examined in the isolated perfused rat adrenal gland. Caffeine (0.3 mM) perfused into an adrenal vein of the gland produced a marked increase in secretion of CA. This secretory effect of CA evoked by perfusion of caffeine for one minute was considerably prolonged, lasting for more than 90 minutes. The tachyphylaxis to releasing effect of CA induced by caffeine was observed by repeated perfusion of this drug. The caffeine-evoked CA secretion was markedly inhibited by pretreatment with ouabain, trifluoperazine, TMB-8 and perfusion with calcium-free Krebs solution containing 5 mM EGTA, but was not affected by perfusion of calcium-free Krebs solution without other addition. CA secretion evoked by caffeine was not reduced significantly by pretreatment with chlorisondamine but after the first collection of perfusate for 3 min was clearly inhibited. Interestingly, the caffeine-evoked CA secretion was considerably potentiated by pretreatment with atropine or pirenzepine, but after the first collection for 3 min it was markedly decreased. These experimental results suggest that caffeine causes a marked increase in secretion of CA from the isolated perfused rat adrenal gland by an extracellular calcium-independent exocytotic mechanism. The secretory effect of caffeine may be mainly due to mobilization of calcium from an intracellular calcium pool in the rat chromaffin cells and partly due to stimulation of both muscarinic and nicotinic receptors.
#Caffeine #catecholamine-secretion #adrenal gland

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