지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: This study aimed to evaluate the toxicity of CP pharmacopunture using bacterial reverse mutation test.
Methods: To determine the mutagenic potential of CP pharmacopunture, histidine requiring Salmonella typhimurium (TA98, TA100, TA1535, and TA1537) and tryptophan requiring Escherichia coli (WP2uvrA, pKM101) strains were used. The negative (normal saline solution) and positive (Sodium azide, 2-Nitrofluorene, 2-Aminoanthracene, 9-Aminoacridine, and 4-Nitroquinoline N-oxide) control groups were used. To determine the dose levels of the main study, a dose range-finding study was conducted.
Results: As a results of the dose range-finding study, the growth inhibition by CP pharmacopunture was not evident at any dose levels in the absence and presence of metabolic activation. As a results of the main study, the mean number of revertant colonies was less than twice when compared to the negative control values at all dose levels of the CP pharmacopuncture in the presence and absence of metabolic activation, showing no dose-related increase. In the positive control group, the number of revertant colonies was markedly increased by more than twice when compared to the negative control group.
Conclusion: According to the results of this study, CP pharmacopunture did not show any signs of mutagenic potential.
Methods: To determine the mutagenic potential of CP pharmacopunture, histidine requiring Salmonella typhimurium (TA98, TA100, TA1535, and TA1537) and tryptophan requiring Escherichia coli (WP2uvrA, pKM101) strains were used. The negative (normal saline solution) and positive (Sodium azide, 2-Nitrofluorene, 2-Aminoanthracene, 9-Aminoacridine, and 4-Nitroquinoline N-oxide) control groups were used. To determine the dose levels of the main study, a dose range-finding study was conducted.
Results: As a results of the dose range-finding study, the growth inhibition by CP pharmacopunture was not evident at any dose levels in the absence and presence of metabolic activation. As a results of the main study, the mean number of revertant colonies was less than twice when compared to the negative control values at all dose levels of the CP pharmacopuncture in the presence and absence of metabolic activation, showing no dose-related increase. In the positive control group, the number of revertant colonies was markedly increased by more than twice when compared to the negative control group.
Conclusion: According to the results of this study, CP pharmacopunture did not show any signs of mutagenic potential.
목차
서론
재료 및 방법
결과
고찰 및 결론
References
참고문헌 (32)
참고문헌 신청
Jung C / 2011 / A clinical study of immune pharmacopuncturology / Kyungrak medical publishing co :127~133
Nam SC / 2009 / Immune Pharmacopuncturology / Kyungrak medical publishing co
2020 / Korean Acupuncture & Moxibustion Society / Hanmi Medical Publishing Co
Ramírez-Barrantes R / 2018 / Transient receptor potential vanilloid 1expression mediates capsaicin-induced cell death / Frontiers in physiology 9:682
Tandan R / 1992 / Topical capsaicin in painful diabetic neuropathy : controlled study with long-term follow-up / Diabetes care 15(1):8~14
Nam SC / 2009 / Immune Pharmacopuncturology / Kyungrak medical publishing co
2020 / Korean Acupuncture & Moxibustion Society / Hanmi Medical Publishing Co
Ramírez-Barrantes R / 2018 / Transient receptor potential vanilloid 1expression mediates capsaicin-induced cell death / Frontiers in physiology 9:682
Tandan R / 1992 / Topical capsaicin in painful diabetic neuropathy : controlled study with long-term follow-up / Diabetes care 15(1):8~14
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UCI(KEPA) : I410-ECN-0101-2020-519-001162407