지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 383 - 390 (8page)
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초록· 키워드
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The safety of a new natural plant composition (ADP) was assessed on the genotoxicity study and 14-day repeat dose toxicity study. ADP contains a mixed water extract obtained from the mixture of Phellodendron cortex (Phellodendron amurense) and Anemarrhena rhizoma (Anemarrhena asphodeloides), and poses the contractile properties mediated by alpha-adrenoceptor of the prostate and urethra as well as antioxidant and anti-inflammatory properties. In order to evaluate genetic safety, in vivo micronucleus test was performed in ICR mice orally administered with three dose levels of 1250, 2500, 5000 mg/kg body weight, and vehicle and positive control. In the 14 days study, Sprague-Dawley rats were treated with ADP at the dose levels of 500, 1000, 2000 mg/kg once a day, and clinical signs, body weights, hematology, serum biochemistry, necropsy findings and organ weights were monitored and examined. In experimental results, ADP treatment, compared with vehicle control, did not induce the micronucleated erythrocytes from mouse bone marrow. In the 14 days study, any significant and toxicological differences in all measurements of parameters were not observed in ADP treatment groups of animals, compared with vehicle treatment. The No-Observed-Adverse-Effect-Level (NOAEL) of ADP in the 14 days study was determined to be greater than 2000 mg/kg/day in both sexes.
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참고문헌 (25)
참고문헌 신청
Ahn D.K / 1998 / Illustrated Book of Korean Medicinal Herbs / Kyo-Hak Publishing Corporation :106
Shen S. / 2013 / Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cells / Biochem. Biophys. Res. Commun 441:519~524
Kang Y. J. / 2011 / Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells / J. Nat. Prod. 74:701~706
Lu W. Q. / 2011 / Antiplatelet and antithrombotic activities of timosaponin B-II, an extract of Anemarrhena asphodeloides / Clin. Exp. Pharmacol. Physiol. 38:430~434
Youn U. J. / 2009 / Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides / J. Nat. Prod 72:1895~1898
Shen S. / 2013 / Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cells / Biochem. Biophys. Res. Commun 441:519~524
Kang Y. J. / 2011 / Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells / J. Nat. Prod. 74:701~706
Lu W. Q. / 2011 / Antiplatelet and antithrombotic activities of timosaponin B-II, an extract of Anemarrhena asphodeloides / Clin. Exp. Pharmacol. Physiol. 38:430~434
Youn U. J. / 2009 / Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides / J. Nat. Prod 72:1895~1898
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