Evaluation of <sup>18</sup>F-FDG PET/CT Parameters for Detection of Lymph Node Metastasis in Cutaneous Melanoma

Cha, Jongtae; Kim, Soyoung; Wang, Jiyoung; Yun, Mijin; Cho, Arthur

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자료유형: 학술저널

저자정보: Cha, Jongtae (Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine) Kim, Soyoung (Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine) Wang, Jiyoung (Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine) Yun, Mijin (Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine) Cho, Arthur (Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine)

저널정보: 대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제52권 제1호

발행연도: 2018.1

수록면: 39 - 45 (7page)

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Purpose The purpose of this study was to investigate the value of $^{18}F$-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) parameters in the detection of regional lymph node (LN) metastasis in patients with cutaneous melanoma. Methods We evaluated patients with cutaneous melanoma who underwent FDG PET/CT for initial staging or recurrence evaluation. A total of 103 patients were enrolled, and 165 LNs were evaluated. LNs that were confirmed pathologically or by follow-up imaging were included in this study. PET parameters, including maximum standardized uptake value (SUVmax), total lesion glycolysis and tumour-to-liver ratio, were used to determine the presence of metastases, and the results were compared with CT-determined LN metastasis. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off values of the FDG PET parameters. Results A total of 93 LNs were malignant, and 84 LNs were smaller than 10 mm. In all 165 LNs, an SUVmax of >2.51 showed a sensitivity of 73.1%, a specificity of 88.9%, and an accuracy of 80.0% in detecting metastatic LNs. CT showed a higher specificity (87.3%) and lower accuracy (65.5%). For non-enlarged regional LNs (<10 mm), an SUVmax cut-off value of 1.4 showed the highest negative predictive value (81.3%). For enlarged LNs (${\geq}10mm$), an SUVmax cut-off value of 2.4 showed the highest sensitivity (90.7%) and accuracy (88.9%) in detecting metastatic LNs. Conclusions In patients with cutaneous melanoma, an SUVmax of >2.4 showed a high sensitivity (91%) and accuracy (89%) in detecting metastasis in LNs ${\geq}1cm$, and LNs <1 cm with an SUVmax <1.4 were likely to be benign.

#Cutaneous melanoma #FDG PET/CT #Lymph node metastasis #Sensitivity

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