지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 163 - 174 (12page)
이용수
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Objectives : Rheum undulatum Linne and Glycyrriza uralensis Fischer are widely used herbal medicine. In this study, anti-oxidant and liver protective effects of R. undunlatum extract (RUE) and G. uralensis extract (GUE) were investigated in HepG2 cells, respectively. Oxidative stress and liver fibrosis were induced by arachidonic acid (AA) and iron, and CCl<sub>4</sub>.Methods : MTT assay was assessed for cell viability, and immunoblotting analysis was performed to detect expression of apoptosis related proteins. In addition, reactive oxygen species (ROS) and mitochondrial dysfunction were measured. In vivo, BALB/c mouse were orally administrated with the aqueous extract of 10 mg/kg RUE and 100 mg/kg GUE for 3 days and then, injected with CCl<sub>4</sub> 0.5 ml/kg body weight to induce acute liver damage. Serum ALT level was measured, and histological change was observed in Harris's hematoxylin and eosin stainResults : RUE and GUE pre-treatment increased relative cell viability in concentration dependent manner and altered the expression levels of apoptosis-related proteins such as procaspase 3, PARP and Bcl-xL. RUE and GUE also inhibited the mitochondrial dysfunction and excessive reactive oxygen species (ROS) production induced by AA and iron. In addition, RUE and GUE activated liver kinase B1 (LKB1), by increasing phosphorylation. Moreover, RUE and GUE treatment decreased liver injuries induced by CCl<sub>4</sub>, as evidenced by decreases in histological liver damage as well as serum alanine amino transferase (ALT) level.Conclusions : These data suggest that RUE and GUE has anti-oxidant and liver protective effects against AA and iron-induced oxidative stress and CCl<sub>4</sub>-induced liver injury.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Halliwell B / 1991 / Reactive oxygen species in living systems: source, biochemistry, and role in human disease / The American journal of medicine 91(3):S14~S22
Lee J / 2004 / Reactive oxygen species, aging, and antioxidative nutraceuticals / Comprehensive reviews in food science and food safety 3(1):21~33
Choi SH / 2010 / AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress / Biochem Pharmacol 79(9):1352~1362
Okuda M / 2002 / Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein / Gastroenterology 122(2):366~375
Kim YW / 2010 / Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPKactivating lignan in Saururus chinensis / Free radical biology & medicine 48(4):567~578
Lee J / 2004 / Reactive oxygen species, aging, and antioxidative nutraceuticals / Comprehensive reviews in food science and food safety 3(1):21~33
Choi SH / 2010 / AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress / Biochem Pharmacol 79(9):1352~1362
Okuda M / 2002 / Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein / Gastroenterology 122(2):366~375
Kim YW / 2010 / Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPKactivating lignan in Saururus chinensis / Free radical biology & medicine 48(4):567~578
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hepatoprotective effects of camellia japonica against acetaminophen-induced acute liver injury in mice
한국실험동물학회 학술발표대회 논문집
2020 .07
-
야교등의 항산화 및 간보호효과
대한한의학방제학회지
2017 .01
-
Liver
대한외과학회 학술대회 초록집
2016 .11
-
Ethanol-induced intestinal miRNAs in liver injury and early development of liver cancer
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .12
-
Steamed ginger extract ameliorates alcohol-induced liver injury in mice via modulation of inflammatory response and oxidative stress
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Preventive effect of silymarin on the restraint-induced liver injury via inhibition of oxidative stress and inflammation in BALB/c mice
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Hepatoprotective effects of Agrimonia eupatoria L. extract on CCl4-induced acute liver injury in mice
한국실험동물학회 학술발표대회 논문집
2020 .02
-
한방병원에 입원한 환자 147명의 간기능 검사에 대한 후향적 관찰
동의생리병리학회지
2018 .12
-
한방병원에 입원한 환자 147명의 간기능 검사에 대한 후향적 관찰
동의생리병리학회지
2018 .01
-
Changes in the Management of Severe Liver Injury: 10-year Experience at a Single Institution
대한외과학회 학술대회 초록집
2021 .11
-
Hepaprotective Effect of Standardized Ecklonia stolonifera Formulation on CCl<sub>4</sub>-Induced Liver Injury in Sprague-Dawley Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Hepatoprotective effect of both aqueous extracted and fermented black radish (Raphanus sativus L. var niger) in CCl4 induced liver injury in rats by attenuating oxidative stress
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Adverse outcome pathways associated with drug-induced liver injury
환경독성보건학회 심포지엄 및 학술대회
2017 .10
-
Amelioration of tunicamycin-induced liver injury by taurine supplementation in mice
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Hepatic compartment syndrome, a rare complication after any liver insult or liver transplantation: Three case reports and literature review
Annals of Hepato-Biliary-Pancreatic Surgery
2024 .08
-
[S15-3] Mouse models for liver cancer; anatomy, modeling, and histopathology
한국실험동물학회 학술발표대회 논문집
2024 .07
-
Successful salvage treatment of acute graft-versus-host disease after liver transplantation by withdrawal of immunosuppression : a case report
Annals of Hepato-Biliary-Pancreatic Surgery
2016 .02
-
비침습적 간섬유화 검사의 적용
대한내과학회지
2023 .04
-
Gut-Liver Axis in Liver Disease
대한외과학회 학술대회 초록집
2019 .10
-
Liver surgery
대한임상종양학회 학술대회지
2020 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0