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논문 기본 정보

자료유형
학술저널
저자정보
Jang, Woo-Seok (Department of Food Science and Biotechnology, Sungkyunkwan University) Song, No-Joon (Department of Food Science and Biotechnology, Sungkyunkwan University) Yoon, Hyang-Jin (Department of Food Science and Biotechnology, Sungkyunkwan University) Kim, Min-Ji (Department of Food Science and Biotechnology, Sungkyunkwan University) Ku, Jin-Mo (Gyeonggi Bio-Center) Hong, Joung-Woo (Graduate School of East-West Medical Science, Kyung Hee University) Lee, Young Min (Department of Agrofood Resources, National Academy of Agricultural Science, RDA) Park, Ki-Moon (Department of Food Science and Biotechnology, Sungkyunkwan University) Park, Kye Won (Department of Food Science and Biotechnology, Sungkyunkwan University)
저널정보
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제55권 제5호
발행연도
2012.1
수록면
625 - 631 (7page)

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Screening of wild vegetable extracts led to isolation of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as putative anti-adipogenic herbal extracts. Cell viability, lipid accumulation, and adipocyte marker expression were determined to validate the effects of the selected extracts on adipogenesis. All extracts suppressed lipid accumulation in C3H10T1/2 cells, primary mouse embryonic fibroblasts, and 3T3-L1 cells in a dose-dependent manner. These extracts inhibited mRNA expression of peroxisome proliferator-activated receptor gamma (PPAR${\gamma}$) and its downstream target genes such as adipocyte protein 2 (aP2), lipoprotein lipase, adiponectin, and CD36. Treatment with these extracts also consistently suppressed PPAR${\gamma}$ and aP2 protein expressions. Additionally, these extracts generated from different parts and/or various harvest periods similarly inhibited adipocyte differentiation. Results showed the extracts have potential beneficial roles in obesity and related metabolic syndromes.

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