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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
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- 1 - 17 (17page)
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Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that exert suppressive function on the immune response. MDSCs expand in tumor-bearing hosts or in the tumor microenvironment and suppress T cell responses via various mechanisms, whereas a reduction in their activities has been observed in autoimmune diseases or infections. It has been reported that the symptoms of various diseases, including malignant tumors, can be alleviated by targeting MDSCs. Moreover, MDSCs can contribute to patient resistance to therapy using immune checkpoint inhibitors. In line with these therapeutic approaches, diverse oligonucleotide-based molecules and small molecules have been evaluated for their therapeutic efficacy in several disease models via the modulation of MDSC activity. In the current review, MDSC-targeting oligonucleotides and small molecules are briefly summarized, and we highlight the immunomodulatory effects on MDSCs in a variety of disease models and the application of MDSC-targeting molecules for immuno-oncologic therapy.
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참고문헌 (149)
참고문헌 신청
Abraham, S. M. / 2006 / Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1 / J. Exp. Med 203:1883~1889
Ali, K. / 2014 / Inactivation of PI(3)K p110delta breaks regulatory T-cell-mediated immune tolerance to cancer / Nature 510:407~411
Anchoori, R. K. / 2013 / A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer / Cancer Cell 24:791~805
Arguello, F. / 1998 / Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts / Blood 91:2482~2490
Azoury, S. C. / 2016 / Molecularly targeted agents and immunotherapy for the treatment of head and neck squamous cell cancer(HNSCC) / Discov. Med 21:507~516
Ali, K. / 2014 / Inactivation of PI(3)K p110delta breaks regulatory T-cell-mediated immune tolerance to cancer / Nature 510:407~411
Anchoori, R. K. / 2013 / A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer / Cancer Cell 24:791~805
Arguello, F. / 1998 / Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts / Blood 91:2482~2490
Azoury, S. C. / 2016 / Molecularly targeted agents and immunotherapy for the treatment of head and neck squamous cell cancer(HNSCC) / Discov. Med 21:507~516
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Mechanisms Underlying the Role of Myeloid-Derived Suppressor Cells in Clinical Diseases: Good or Bad
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Analysis of the Expression and Regulation of PD-1 Protein on the Surface of Myeloid-Derived Suppressor Cells (MDSCs)
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Exploring the Potential of Glycolytic Modulation in Myeloid-Derived Suppressor Cells for Immunotherapy and Disease Management
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IL-12 Enhances Immune Response by Modulation of Myeloid Derived Suppressor Cells in Tumor Microenvironment
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Expansion of Myeloid-Derived Suppressor Cells Correlates with Renal Progression in Type 2 Diabetic Nephropathy
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Myeloid-Derived Suppressor Cells Recruited by Chemokine (C-C Motif) Ligand 3 Promote the Progression of Breast Cancer via Phosphoinositide 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling
Journal of Breast Cancer
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Immune suppression by myeloid-derived suppressor cells in cancer
한국실험동물학회 학술발표대회 논문집
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The inhibition of MDSC and M2 macrophage by metformin is mediated by AMPK-induced inhibition of HMG-CoA reductase
한국실험동물학회 학술발표대회 논문집
2016 .08
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Myeloid derived suppressor cells are controlled by regulatory T cells via TGF-β during murine colitis
한국실험동물학회 학술발표대회 논문집
2017 .02
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Tumor Induces the Expansion of Foxp3+CD25high and CD11b+Gr-1+ Cell Population in the Early Phase of Tumor Progression
대한의생명과학회지
2015 .12
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Immunomodulatory effect of captopril and local irradiation on myeloid-derived suppressor cells
Radiation oncology journal : ROJ
2016 .01
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Granulocytic and Monocytic Myeloid-Derived Suppressor Cells are Functionally and Prognostically Different in Patients with Chronic Myeloid Leukemia
Annals of Laboratory Medicine
2021 .09
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Effect of Cisplatin on the Frequency and Immuno-inhibitory Function of Myeloid-derived Suppressor Cells in A375 Melanoma Model
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Association of Chemokines and Chemokine Receptor Expression with Monocytic-Myeloid-Derived Suppressor Cells during Tumor Progression
Immune Network
2018 .06
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Altered Biological Potential and Radioresponse of Murine Tumors in Different Microenvironments
Cancer Research and Treatment
2016 .01
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Murine Mammary Carcinoma Induces Chronic Systemic Inflammation and Immunosuppression in BALB/c Mice
Journal of Breast Cancer
2022 .06
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Myeloid-derived suppressor cells and immune regulation in cancer
한국실험동물학회 학술발표대회 논문집
2018 .01
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Single Molecule Method for Molecular Biology
International Journal of Oral Biology
2018 .01
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Recent Advances in Cell Therapeutics for Systemic Autoimmune Diseases
Immune Network
2022 .02
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Attenuation of Hepatic Graft-versus-host Disease in Allogeneic Recipients of MyD88-deficient Donor Bone Marrow
Immune Network
2015 .06
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