지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In this study, we investigated PLGA/graphene composite scaffold prepared by electrospinning method for its possible application in biomedical fields. Mixture of 16 wt% PLGA and 0.1~1.0 wt% well-dispersed graphene dissolved in 1,2-dichloroethane co-solvent was used as a dope solution for fabricating a mat type of electrospun PLGA/graphene composite scaffold. The morphological structure of the composite scaffold was examined by FE-SEM, indicating that monolayered graphene was well hybridized inside the PLGA microfiber (ca. 900~1000 nm fiber size). Indirect evidence of graphene inclusion in the composite scaffold was confirmed by X-ray diffraction analysis and thermal gravimetric analysis quantitatively. As a result of tensile test, the PLGA/graphene composite scaffold had an excellent tensile strength (2~2.5 times higher), breaking strain (2.5~3.5 times higher) and Young's modulus (1.2~2.4 times higher) compared to electrospun PLGA scaffold. Cytotoxicity and cell proliferation of the composite scaffold were also performed by MTT assay using MC3T3-E1 and NIH3T3 cell, showing that graphene-containing PLGA scaffold has no cytotoxicity and even much better cell adhesion and proliferation ability. Therefore, it is concluded that the electrospun PLGA/graphene composite scaffold can be potentially used in biomedical applications for tissue engineering, due to excellent mechanical properties as well as high cell compatibility.
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참고문헌 (13)
참고문헌 신청
T. Kuilla / 2010 / Recent Advances in Graphene Based Polymer Composites / Prog Polym Sci 35:1350~1375
K. S. Kim / 2009 / Large-scale Pattern Growth of Graphene Films for Stretchable Transparent Electrodes / Nature 457:706~710
X. Lu / 1990 / Tailoring Graphite with the Goal of Achieving Single Sheets / Nanotechnology 10:269~272
C. D. Reddy / 2006 / Equilibrium Configuration and Continuum Elastic Properties of Finite Sized Graphene / Nanotechnology 17:864~870
T. R. Nayak / 2011 / Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells / ACSNano 5(6):4670~4678
K. S. Kim / 2009 / Large-scale Pattern Growth of Graphene Films for Stretchable Transparent Electrodes / Nature 457:706~710
X. Lu / 1990 / Tailoring Graphite with the Goal of Achieving Single Sheets / Nanotechnology 10:269~272
C. D. Reddy / 2006 / Equilibrium Configuration and Continuum Elastic Properties of Finite Sized Graphene / Nanotechnology 17:864~870
T. R. Nayak / 2011 / Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells / ACSNano 5(6):4670~4678
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