지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 168 - 178 (11page)
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초록· 키워드
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Objectives : Mahuang-Chuanwu(Mahwang-Cheonoh) Pharmacopuncture(MCP) has been used to treat obesity in Clinical Korean Medicine. MCP solution(MCPS) is also expected to have strong anti-obesity activities. However, little is known about the mechanisms of its inhibitory effects on adipocyte differentiation and lipogenesis. Methods : In the present study, we examined the effects of MCPS on differentiation and lipogenesis of 3T3-L1 adipocytes. To elucidate the mechanism of the effects of MCPS on lowering lipid content in 3T3-L1 adipocytes, we examined whether MCPS modulates the expressions of transcription factors to induce lipogenesis and adipogenic genes related to regulate the accumulation of lipids. Results : Our results showed that MCPS significantly inhibited differentiation and lipogenesis of 3T3-L1 adipocytes in a dose-dependent manner. MCPS suppressed the mRNA expressions of cytidine-cytidine-adenosine-adenosine-thymidine(CCAAT)/enhancer binding proteins ${\alpha}$($C/EBP{\alpha}$), C/EBP ${\beta}$, $C/EBP{\delta}$, and peroxisome proliferator-activated receptor ${\gamma}$($PPAR{\gamma}$) genes related to the induction of adipose differentiation. MCPS inhibited the mRNA expressions of adipose-specific aP2, adipsin, lipoprotein lipase(LPL), CD36, TGF-${\beta}$, and leptin genes related to the fat formation. MCPS downregulated the mRNA expressions of liver X receptor(LXR) ${\alpha}$ and fatty acid synthase(FAS) genes related to the induction of lipogenesis. In addition, MCPS reduced the production of adipocyte-induced pro-inflammatory cytokines. Conclusions : MCPS could regulate the accumulation of lipids and expression of adipogenic genes via inhibition of transcript factors related to induction of adipose differentiation.
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참고문헌 (29)
참고문헌 신청
Haslam D / 2006 / Obesity--time to wake up / BMJ 333:640~642
Korean Pharmacopuncture Institute / 2011 / Pharmacopuncturology:Principles and Clinical Applications / Elsevier Korea LLC :6~8
Jang IS / 2007 / The Need for Clinical Practice Guidelines in Usage of Mahuang in Weight Loss / Journal of Society of Korean Medicine for Obesity Research 7:23~29
Kim HJ / 2007 / A Clinical Practice Guideline for Ma-huang(Ephedra sinica) Prescription in Obesity / Journal of Society of Korean Medicine for Obesity Research 2:27~37
Textbook Compilation Committee of National Universitiy of Korean Medicine / 1991 / Herbology / Yeonglimsa :121~123
Korean Pharmacopuncture Institute / 2011 / Pharmacopuncturology:Principles and Clinical Applications / Elsevier Korea LLC :6~8
Jang IS / 2007 / The Need for Clinical Practice Guidelines in Usage of Mahuang in Weight Loss / Journal of Society of Korean Medicine for Obesity Research 7:23~29
Kim HJ / 2007 / A Clinical Practice Guideline for Ma-huang(Ephedra sinica) Prescription in Obesity / Journal of Society of Korean Medicine for Obesity Research 2:27~37
Textbook Compilation Committee of National Universitiy of Korean Medicine / 1991 / Herbology / Yeonglimsa :121~123
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