The role of the supramammillary area of the hypothalamus in cognitive functions

Shim, Hyun Soo; Park, Hyun-Jung; Lee, Mi-Sook; Ye, Minsook; Shim, Insop

추천

검색

자료유형: 학술저널

저자정보: Shim, Hyun Soo (Department of Physiology, College of Medicine, Kyung Hee University) Park, Hyun-Jung (Department of Physiology, College of Medicine, Kyung Hee University) Lee, Mi-Sook (Department of Physiology, College of Medicine, Kyung Hee University) Ye, Minsook (Department of Physiology, College of Medicine, Kyung Hee University) Shim, Insop (Department of Physiology, College of Medicine, Kyung Hee University)

저널정보: 한국통합생물학회 Animal cells and systems Animal cells and systems 제22권 제1호

발행연도: 2018.1

수록면: 37 - 44 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

The supramammillary area (SUM) of the hypothalamus has wide spread connection with numerous brain structures. It is known that the SUM can control the frequency of the hippocampal theta rhythm, which plays a role in the cognitive functions of the hippocampal formation. In order to examine the role of the specific cells of the SUM in learning and memory, selective cholinergic neurotoxic or excitotoxic lesioned rats of the SUM were tested for spatial memory on the Morris water maze (MWM) test. After the behavior tests, the expression of acetylcholinesterase (AChE) in the hippocampus was studied using the immunohistochemistry. In the MWM test, both lesion of the SUM with 192 IgG-saporin or ibotenic acid produced the impairment of spatial learning and memory. The expression of AChE immunreactive neurons in the hippocampal CA3 region was decreased after injections of 192 IgG-saporin into the SUM. These findings suggest that cholinoceptive cells of the SUM area may play a critical role in the process of learning and memory.

#Supramammillary area #SUM) #acetylcholinesterase #AChE) #hypothalamus #Morris water maze #MWM) #192 IgG-saporin

참고문헌 (37)

참고문헌 신청

Aranda L / 2008 / Temporary inactivation of the supramammillary area impairs spatial working memory and spatial reference memory retrieval / Physiol Behav 94:322~330

Aranda L / 2006 / Supramammillary and adjacent nuclei lesions impair spatial working memory and induce anxiolitic-like behavior / Behav Brain Res 167:156~164

Ariffin MZ / 2010 / Nicotinic receptor mechanism in supramammillary nucleus mediates physiological regulation of neural activity in dorsal hippocampal field CA1 of anaesthetized rat / Hippocampus 20:852~865

Berger B / 2001 / Human and monkey fetal brain development of the supramammillary-hippocampal projections: a system involved in the regulation of theta activity / J Comp Neurol 429:515~529

Borhegyi Z / 1997 / The supramammillary nucleus innervates cholinergic and GABAergic neurons in the medial septum-diagonal band of Broca complex / Neuroscience 82:1053~1065

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!