지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Ligusticum chuanxiong (Umbelliferae) is a perennial herb that has been used for invigoration of blood in Korean traditional medicine. It is especially important in gynecological therapy of amenorrhea and dysmenorrhea. In this study, the essential oil of L. chuanxiong was obtained by steam distillation and its main components of L. chuanxiong, Z-ligustilide and butylidene phthalide, were isolated by silica gel column chromatography. We investigated the cytotoxic effects of the essential oil fraction of L. chuanxiong and its main components on MCF-7, HeLa and SK-Hep-1 cell lines by measuring the number of surviving cancer cells after treatment through direct cell counting and MTT analysis, and by examining the morphological changes under the microscope. The essential oil from the rhizomes of L. chuanxiong and its main components showed significant cytotoxic activities for all three tested cell lines. We also observed morphological changes of shrinking and blebbing in the membranes of the three cell lines, depending on the concentration of L. chaunxiong oil or its main components.
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참고문헌 (31)
참고문헌 신청
Cui, F. / 2006 / Factors affecting stability of Zligustilide int eht volatile of Radix Angelicae sinensis and Ligusticum chuanxiong and its stability prediction / Drug Dev. Ind. Pharm 32:747
Zschocke, S / 2005 / HPLCcoupled spectroscopic techniques IUV, IR, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong / Mol. Divers 9:33
Lu, Q / 2006 / Z-ligustilide inhibits vascular smooth muscle cell proliferation / Eur. J. Pharm 542:136
Hou, Y.-Z / 2005 / Inhibition of rat vascular smooth muscle cell proliferation by extract of Ligusticum chuanxiong and Angelica sinensis / J. Ethnopharmacol 100:140
Ozaki, Y / 1989 / Centrally acting muscle relaxant effect of phthalides (Z-ligustilide, cnidilide and senkyunolide) obtained from Cnidium officinale Makino / J. Pharm. Soc. Jap 109:402
Zschocke, S / 2005 / HPLCcoupled spectroscopic techniques IUV, IR, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong / Mol. Divers 9:33
Lu, Q / 2006 / Z-ligustilide inhibits vascular smooth muscle cell proliferation / Eur. J. Pharm 542:136
Hou, Y.-Z / 2005 / Inhibition of rat vascular smooth muscle cell proliferation by extract of Ligusticum chuanxiong and Angelica sinensis / J. Ethnopharmacol 100:140
Ozaki, Y / 1989 / Centrally acting muscle relaxant effect of phthalides (Z-ligustilide, cnidilide and senkyunolide) obtained from Cnidium officinale Makino / J. Pharm. Soc. Jap 109:402
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