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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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HER-2 (Human Epidermal Growth Factor Receptor-2) is a protein giving higher aggressiveness in human breast cancers. Trastuzumab is a monoclonal antibody that targets HER-2 and is known to extend survival across all stages of HER2-positive breast cancer. In this study, we attempted to development of a quantitative ELISA (Enzyme-Linked ImmunoSorbent Assay) for evaluating anti HER-2 antibodies using human HER-2 recombinant proteins to support antibody producing processes and pharmacokinetic studies. We established direct or indirect ELISA method for the trastuzumab-like protein combined human recombinant HER-2. The ELISA method will prove to be great value in quantitating anti-HER-2 antibodies levels for developing anticancer antibodies.
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참고문헌 (17)
참고문헌 신청
King, C. R / 1985 / Amplification of a novel v-erbB-related gene in a human mammary carcinoma / Science 229:974
Slamon, D. J. / 1987 / Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene / Science 235:177
Di Fiore, P. P / 1987 / erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells / Science 237:178
Slamon, D. J / 1989 / Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer / Science 244:707
Moasser, M. M / 2007 / The oncogene HER-2: its signaling and transforming functions and its role in human cancer pathogenesis / Oncogene 26:6469
Slamon, D. J. / 1987 / Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene / Science 235:177
Di Fiore, P. P / 1987 / erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells / Science 237:178
Slamon, D. J / 1989 / Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer / Science 244:707
Moasser, M. M / 2007 / The oncogene HER-2: its signaling and transforming functions and its role in human cancer pathogenesis / Oncogene 26:6469
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