지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In the present studies, we examined effect of chamomile flowers extract (CH-Ex), which has traditionally been used as antiphlogistics in Europe for many centuries, against Candida albicans-caused septic arthritis. Candida albicans is a major etiological agent among fungal septic arthritis. This effect was investigated in a murine model of the septic arthritis. That is, mice that were given an emulsion form of C. albicans cell wall (CACW) via footpad route were treated intraperitoneally with the CH-Ex for 3 times every 3 days. Degrees of the footpad-swellings were measured with dial gauger. Data showed that the CH-Ex resulted in the reduction of swelling. For instance, at Day 9 when swelling reached the highest peak, there was up to app. 60% reduction of edema in mice injected with the CH-Ex, compared to that of the control mice that received no treatment (P<0.05). This therapeutic anti-arthritic activity appeared to be mediated by inhibitions of NO (nitric oxide) production from activated RAW264.7 macrophages and proliferation of Con A-treated T lymphocytes. Analysis by HPLC revealed that the CH-Ex contained eight polyphenolic compounds including chlorogenic acid (CRA) and rutin. We have reported the CRA and rutin respectively have the anti-arthritic activity. This correlation implicates that CRA and rutin in the CH-Ex may be responsible for the activity. Combined all together, the CH-Ex has anti-arthritic activity against C. albicans-caused septic arthritis, possibly by inhibiting NO production and proliferation of T cells. This activity seems to be contributed by, at least, CRA and rutin among the compounds in the CH-Ex.
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참고문헌 (31)
참고문헌 신청
Cuende, E. / 1993 / Candida arthritis in adult patients who are not intravenous drug addicts: report of three cases and review of the literature / Semin Arthritis Rheum 22:224
Lerch, K. / 2003 / Prosthetic joint infection with osteomyelitis due to Candida albicans / Mycoses 46:462
Azaceta, G. / 1999 / Successful lipid-complexed amphotericin B treatment of Candida arthritis in a lymphoma patient / Rev. Rhum. Engl 66:434
Choi, I. S. / 2000 / Candida polyarthritis in a renal transplant patient: case report of a patient successfully treated with amphotericin B / Transplant Proc 32:1963
Lee, D. M. / 2001 / Rheumatoid arthritis / Lancet 358:903
Lerch, K. / 2003 / Prosthetic joint infection with osteomyelitis due to Candida albicans / Mycoses 46:462
Azaceta, G. / 1999 / Successful lipid-complexed amphotericin B treatment of Candida arthritis in a lymphoma patient / Rev. Rhum. Engl 66:434
Choi, I. S. / 2000 / Candida polyarthritis in a renal transplant patient: case report of a patient successfully treated with amphotericin B / Transplant Proc 32:1963
Lee, D. M. / 2001 / Rheumatoid arthritis / Lancet 358:903
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