지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
We investigated whether poly-L-histidine (PLH) significantly affect mucin release from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with $^$^3H$$glucosamine for 24 hr and chased for 30 min in the presence of PLH to assess the effect on $^3H$-mucin release. PLH 9,850 and PLH 6,700 specifically inhibit mucin release from airway goblet cells without significant cytotoxicity. This finding suggests that poly-L-histidine might function as an airway mucoregulative agent.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Ellis, E. F / 1985 / Asthma in childhood / J. Allergy. Clin. Immunol 72:526
Mutschler, E / 1995 / Drug actions / CRC press,Inc
Ko, K. H / 1999 / Inhibition of mucin release from airway goblet cells by polycationic peptides / Am. J. Physiol 277(21):811
Kim, K. C / 1985 / Biochemical characterization of mucous glycoproteins synthesized and secreted by hamster tracheal epithelial cells in primary culture / J. Biol. Chem 260:4021
Kim, K. C / 1989 / Secretions from primary hamster tracheal surface epithelial cells in culture: Mucin-like glycoproteins, proteoglycans, and lipids / Exp. Lung Res 15:299
Mutschler, E / 1995 / Drug actions / CRC press,Inc
Ko, K. H / 1999 / Inhibition of mucin release from airway goblet cells by polycationic peptides / Am. J. Physiol 277(21):811
Kim, K. C / 1985 / Biochemical characterization of mucous glycoproteins synthesized and secreted by hamster tracheal epithelial cells in primary culture / J. Biol. Chem 260:4021
Kim, K. C / 1989 / Secretions from primary hamster tracheal surface epithelial cells in culture: Mucin-like glycoproteins, proteoglycans, and lipids / Exp. Lung Res 15:299
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