지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. In the present study, we investigated the neuroprotective effects of the standard extracts of Taraxacum officinale Weber, one of the original plants of Taraxaci Herba, on glutamate-induced oxidative injury in mouse hippocampal HT22 cells. The standard EtOH extract of the aerial parts of T. officinale (NNMBS270) showed significant cytoprotective effects on glutamate-induced neurotoxicity and induced the expression of heme oxygenase (HO)-1 in the mouse hippocampal HT22 cells, while the roots' extract (NNMBS271) did not show neuroprotective effect. These results suggest that the extract of the aerial parts of T. officinale could be an effective candidate for the treatment of ROS-related neurological diseases.
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참고문헌 (23)
참고문헌 신청
Bae, K. H / 2000 / The medicinal plants of Korea / Kyohak Pub. Co., Seoul
Lee, E. B. / 1993 / The antigastritic effect of Taraxaci Herba / Kor. J. Pharmacogn 24:313
Kang, M. J / 2001 / Current trends of research and biological activities of dandelion / Food Ind. Nutr 6:60
Ahmad, V. U / 2000 / Taraxacin, a new guaianolide from Tarazacum wallichii / J. Nat. Prod 63:1010
Kim, T. J / 1996 / Korean resources plants / Seoul National University Pub. Co., Seoul
Lee, E. B. / 1993 / The antigastritic effect of Taraxaci Herba / Kor. J. Pharmacogn 24:313
Kang, M. J / 2001 / Current trends of research and biological activities of dandelion / Food Ind. Nutr 6:60
Ahmad, V. U / 2000 / Taraxacin, a new guaianolide from Tarazacum wallichii / J. Nat. Prod 63:1010
Kim, T. J / 1996 / Korean resources plants / Seoul National University Pub. Co., Seoul
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