지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Isoquinoline compounds including berberine enhance L-DOPA-induced cytotoxicity in PC12 cells. In this study, the effects of berberine on L-DOPA therapy in unilateral 6-hydroxydopamine (6-OHDA)-induced rat models of parkinsonism were investigated. Rats were prepared for the models of Parkinson's disease by 6-OHDA-lesioning for 14 days and then treated with L-DOPA (10 mg/kg) with or without berberine (5 and 30 mg/kg, i.p.) for 21 days. Treatment with berberine (5 and 30 mg/kg, i.p.) showed a dopaminergic cell loss in substantia nigra of 6-OHDA-lesioned rats treated with L-DOPA: 30 mg/kg berberine was more intensive neurotoxic. The levels of dopamine were also decreased by berberine (5 and 30 mg/ kg) in striatum-substantia nigra of 6-OHDA-lesioned rats treated with L-DOPA. These results suggest that berberine aggravates cell death of dopaminergic neurons in L-DOPA-treated 6-OHDA-lesioned rat models of Parkinson's disease. Therefore, the long-term L-DOPA therapeutic patients with isoquinoline compounds including berberine may need to be checked for the adverse symptoms.
목차
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참고문헌 (26)
참고문헌 신청
Fearnley, M / 1991 / Ageing and Parkinson's disease: substantia nigra regional selectivity / Brain 114:2283
Jung, Y. J / 2001 / Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid / Free Rad. Biol. Med 30:1407
McNaught, K. S / 1998 / Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease / Biochem. Pharmacol 56:921
Shin, J. S / 2000 / Inhibition of dopamine biosynthesis by protoberberine alkaloids in PC12 cells / Neurochem. Res 25:363
이명구 / 200412 / Enantio-selective inhibition of (1R,9S)- and (1S,9R)-beta-hydrastines on dopamine biosynthesis in PC12 cells / NEUROPHARMACOLOGY 47:1045
Jung, Y. J / 2001 / Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid / Free Rad. Biol. Med 30:1407
McNaught, K. S / 1998 / Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease / Biochem. Pharmacol 56:921
Shin, J. S / 2000 / Inhibition of dopamine biosynthesis by protoberberine alkaloids in PC12 cells / Neurochem. Res 25:363
이명구 / 200412 / Enantio-selective inhibition of (1R,9S)- and (1S,9R)-beta-hydrastines on dopamine biosynthesis in PC12 cells / NEUROPHARMACOLOGY 47:1045
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