지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
We previously reported that the novel isoflavone-free peptide mixture (black soybean peptide, BSP) had several beneficial effects like antiobesity and hypotriglyceridemic effect. However, there are no reports for BSP on anti-hypertensive activity. BSP induced heme oxygenase-1 (HO-1) in HUVECs, thus investigated the HO-1-induced activity in HUVECs and the anti-hypertensive effects in SHR animal model. BSP significantly induced HO-1 expression both at transcriptional and protein levels in a time- and dose-dependent manner as measured by RT-PCR and Western blot analysis, respectively. These inductions were abolished by pretreatment of N-acetyl-cystein (NAC, 1~10 mM), but not by employing Tempol, a superoxide dismutase (SOD) mimetic (1~5 mM). As expected, enzymatic activity (~2 fold) determined by bilirubin formation assay and cGMP concentration (~6 fold) were significantly increased in BSP-treated cells. Based on the numerous evidences on the beneficial effects of HO-1 and our results, we investigated in vivo effects of BSP on the antihypertensive activity. The administration of BSP (1% in drinking water) significantly decreased mean blood pressure (BP) (from $218.6{\pm}6.99$ to $190.0{\pm}3.42$ mm Hg, p<0.01). This result indicates that BSP is strong inducer of HO-1 expression, which may be triggered by oxidative stress, and has anti-hypertensive activity.
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참고문헌 (32)
참고문헌 신청
Redon, J. / 2009 / Mechanisms of hypertension in the cardiometabolic syndrome / J. Hypertens 27:441
Bornstein, N. / 2006 / Arterial hypertension and stroke prevention: an update / Clin. Exp. Hypertens 28:317
Birkenhäger, W. H. / 2006 / Progress in cardiovascular diseases: cognitive function in essential hypertension / Prog. Cardiovasc. Dis 49:1
Blacher, J. / 2005 / New treatment strategies for hypertension. Which guidelines and how to apply them / Presse. Med 34:1279
Panza, J. A. / 1993 / Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension / Circulation 87:1475
Bornstein, N. / 2006 / Arterial hypertension and stroke prevention: an update / Clin. Exp. Hypertens 28:317
Birkenhäger, W. H. / 2006 / Progress in cardiovascular diseases: cognitive function in essential hypertension / Prog. Cardiovasc. Dis 49:1
Blacher, J. / 2005 / New treatment strategies for hypertension. Which guidelines and how to apply them / Presse. Med 34:1279
Panza, J. A. / 1993 / Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension / Circulation 87:1475
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