지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Enviromental differences in gentamicin pharmacokinetics by using population pharmacokinetic methods were compared with 20 Korean patients and 24 Korean-American appendicitis patients. Two to six blood specimens were collected from all patients at the following times : just before a regularly scheduled infusion and at 0.5 hour after the end of a 0.5 hour infusion. Nonparametric expected maximum (NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constant (K), the slope (KS) of the relationship between K versus creatinine clearance ($C_{cr}$), the apparent volume of distribution (V), the slope (VS) of the relationship between V versus weight, gentamicin clearance (CL) and the slope (CS) of the relationship between CL versus $C_{cr}$ and the V. The output includes two marginal probability density function (PDF), means, medians, modes, variance and CV%. The mean K (KS) were $0.402{\pm}0.129\;h^{-1}(0.00486{\pm}0.00197\;[h{\cdot}ml/min/1.73\;m^2]^{-1})$ and $0.411{\pm}0.135\;h^{-1}(0.00475{\pm}0.00180\;[h{\cdot}ml/min/1.73\;m^2]^{-1})$ for Korean and Korean-American populations, respectively. The mean V (VS) were not different at $14.3{\pm}3.6l(0.241{\pm}0.0511l/kg)$ and $15.1{\pm}3.84l(0.239{\pm}0.0492l/kg)$ for Korean and Korean-American populations, respectively (p>0.2). The mean CL (CS) were $5.68{\pm}1.69l/h(0.0714{\pm}0.0222l/kg[h{\cdot}ml/min/1.73\;m^2])$ and $5.70{\pm}1.77l/h(0.0701{\pm}0.0215l/kg[h{\cdot}ml/min/1.73\;m^2])$ for Korean and Korean-American populations, respectively. There were no enviromental differences in gentamicin pharmacokinetics between Korean and Korean-American appendicitis patients.
목차
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참고문헌 (34)
참고문헌 신청
Sheiner, B. B. / 1979 / Forecasting individual pharmacokinetics / Clin. Pharmacol. Ther 31:294
Hurst, A. / 1990 / Application of a bayesian method to monitor and adjust vancomycin dosage regimens / Antimicrob. Agents Chemother 34:1165
Touw, D. J. / 2001 / Gentamicin pharmacokinetics in preterm infants with a patent and a closed ductus arteriosus / Pharm. World Sci 23:200
Nielsen, E. I. / 2009 / Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study / Clin. Pharmacokinet 48:253
Seaton, C. / 2007 / Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition / J. Antimicrob. Chemother 59:681
Hurst, A. / 1990 / Application of a bayesian method to monitor and adjust vancomycin dosage regimens / Antimicrob. Agents Chemother 34:1165
Touw, D. J. / 2001 / Gentamicin pharmacokinetics in preterm infants with a patent and a closed ductus arteriosus / Pharm. World Sci 23:200
Nielsen, E. I. / 2009 / Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study / Clin. Pharmacokinet 48:253
Seaton, C. / 2007 / Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition / J. Antimicrob. Chemother 59:681
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