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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Middle East respiratory syndrome - coronavirus infection has posed substantial threat to public health with extremely high mortality rate in 2015. Although there are no approved novel medications for coronavirus, several antiviral agents such as ribavirin and interferon have been tried to MERS patients according to the in-vitro inhibitory effect, therapeutic effect on the animal model and experience from the severe acute respiratory syndrome - coronavirus infection. The aim of this study is to evaluate the clinical evidence of the antiviral treatment for MERS-CoV infection. After systematically searching the medical literature databases, I found five studies described the clinical efficacy of antiviral treatment on MERS patients. All of them were about the combination therapy of ribavirin and interferon (IFN). Two of them were retrospective cohort studies with quality of evidence (QOE) II and the others were observational study and case reports with QOE III. As a result of critical appraisal, it is concluded that none of those studies represented confirmatory clinical evidence of the efficacy of ribavirin and interferon combination therapy on MERS patients. Although Omrani et al. represented that ribavirin and IFN treatment had significantly improved survival at 14 days, it was not enough time to conclude the effect.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Al-Tawfiq, J. A / 2014 / Surveillance for emerging respiratory viruses / Lancet Infect. Dis 14:992
Assiri, A / 2013 / KSA MERS-CoV Investigation Team.: Hospital outbreak of Middle East respiratory syndrome coronavirus / N. Engl. J. Med 369:407
Assiri, A / 2013 / Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study / Lancet Infect. Dis 13:752
Memish, Z. A / 2014 / Middle East respiratory syndrome coronavirus disease in children / Pediatr. Infect. Dis. J 33:904
Zumla, A / 2014 / Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options / Lancet Infect. Dis 14:1136
Assiri, A / 2013 / KSA MERS-CoV Investigation Team.: Hospital outbreak of Middle East respiratory syndrome coronavirus / N. Engl. J. Med 369:407
Assiri, A / 2013 / Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study / Lancet Infect. Dis 13:752
Memish, Z. A / 2014 / Middle East respiratory syndrome coronavirus disease in children / Pediatr. Infect. Dis. J 33:904
Zumla, A / 2014 / Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options / Lancet Infect. Dis 14:1136
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