지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The objective of this study is to evaluate the anticancer effects of the isoflavone extract from Chungkukjang in human breast cancer, MDA-MB-453 cells. For this study, MDA-MB-453 cells were treated with 12.5, 25, and $50{\mu}g$ isoflavone extract for 24, 48, and 72 hr. Cell proliferations were decreased in a time- and dose-dependent manner. Reduced cell proliferation was suspected by apoptosis or cell cycle arrest. Therefore, after treatment of $50{\mu}g$ isoflavone extract, apoptotic cells were investigated by annexin V staining. The results indicated that isoflavone extract increased the number of early apoptotic cells compared with control. Cleaved PARP was also increased. Next, we investigated the cell cycle and related proteins. The isoflavone extract leads to cell cycle arrest at the G2/M phase. Moreover isoflavone extract had influenced cell cycle relate proteins such as cyclin B1, cyclin A, and p21. These results suggest that isoflavone extract from Chungkukjang induce apoptosis and cell cycle arrest at G2/M phase via regulation of cell cycle-related proteins in MDA-MB-453 cells.
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참고문헌 (29)
참고문헌 신청
Wada, K. / 2013 / Soy isoflavone intake and breast cancer risk in Japan: from the Takayama study / Int. J. Cancer 13:952
Nagata, C. / 2010 / Factors to consider in the association between soy isoflavone intake and breast cancer risk / J. Epidemiol 20:83
Messina, M. J. / 1994 / Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr / Cancer 21:133
Kao, T. H. / 2007 / Anti-inflammatory effects of isoflavone powder produced from soybean cake / J. Agric. Food Chem 55:11068
Messina, M. / 1991 / Increasing use of soyfoods and their potential role in cancer prevention / J. Am. Diet Assoc 91:836
Nagata, C. / 2010 / Factors to consider in the association between soy isoflavone intake and breast cancer risk / J. Epidemiol 20:83
Messina, M. J. / 1994 / Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr / Cancer 21:133
Kao, T. H. / 2007 / Anti-inflammatory effects of isoflavone powder produced from soybean cake / J. Agric. Food Chem 55:11068
Messina, M. / 1991 / Increasing use of soyfoods and their potential role in cancer prevention / J. Am. Diet Assoc 91:836
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