지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
To investigate the possibility of development as a whitening agent using arctigenin, we measured DPPH assay, NBT/XO assay, intracellular ROS scavenging assay, tyrosinase assay and MSH-induced melanin production in B16 melanoma cells. Arctigenin dose-dependently had anti-oxidant activity in DPPH, NBT/XO and intracellular ROS assay. Although arctigenin did not inhibit purified tyrosinase activity, it dose-dependently inhibited tyrosinase activity and melanin production in B16 melanoma cells stimulated by $1{\mu}M$ ${\alpha}$-MSH. In particular, arctigenin at a concentration $100{\mu}M$ inhibited ${\alpha}$-MSH-stimulated tyrosinase activity and melanin production by $50.9{\pm}2.9%$ and $69.0{\pm}6.5%$ respectively. And typical tyrosinase inhibitor, arbutin, inhibited $57.7{\pm}2.9%$ and $65.1{\pm}5.0%$ respectively. Such an similar inhibitory effect of arctigenin and arbutin in B16 melanoma cells may be due to the inhibition of MSH signal pathway rather than the direct inhibition of tyrosinase. Therefore, these results suggest that arctigenin may be useful for the development as whitening agents.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Swarup, V. / 2008 / Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan / J. Antimicrob. Chemother 61:679
Kou, X. / 2011 / Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway / Int. Immunopharmacol 11:1095
Kang, H. S. / 2008 / Anti-inflammatory activity of arctigenin from Forsythiae Fructus / J. Ethnopharmacol 116:305
Kim, J. Y. / 2010 / Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity / J. Cell. Physiol 224:33
Charlton, J. L. / 1998 / Antiviral activity of lignans / J. Nat. Prod 61:1447
Kou, X. / 2011 / Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway / Int. Immunopharmacol 11:1095
Kang, H. S. / 2008 / Anti-inflammatory activity of arctigenin from Forsythiae Fructus / J. Ethnopharmacol 116:305
Kim, J. Y. / 2010 / Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity / J. Cell. Physiol 224:33
Charlton, J. L. / 1998 / Antiviral activity of lignans / J. Nat. Prod 61:1447
이 논문의 저자 정보
최근 본 자료
댓글(0)
0