메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Kim, Seok Jai (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) Li, Mei (Department of Anesthesiology, The First Affiliated Hospital and Zhejiang University Medical School) Jeong, Cheol Won (Department of Anesthesiology and Pain Medicine, Chonnam National University Dental School) Bae, Hong Beom (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) Kwak, Sang Hyun (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) Lee, Seong Heon (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) Lee, Hyun Jung (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) Heo, Bong Ha (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) Yook, Keun Bae (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) Yoo, Kyung Yeon (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제37권 제8호
발행연도
2014.1
수록면
1,079 - 1,085 (7page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, has been shown to modulate numerous molecular targets in the setting of inflammation. This study aimed to determine whether EGCG protects against regional myocardial ischemia/reperfusion (I/R) injuries and its underlying mechanisms involving the role of reperfusion injury salvage kinase (RISK) pathways (PI3K-Akt and ERK 1/2) and $GSK-3{\beta}$ or apoptotic kinases (p38 and JNK). The rats were subjected to I/R injuries consisting of 30 min ischemia followed by 2 h reperfusion. EGCG (10 mg/kg, intravenously) was administered alone or along with wortmannin (PI3K inhibitor, 0.6 mg/kg, intravenously) 5 min before the onset of reperfusion. Wortmannin was administered 10 min before the reperfusion. Infarct size was measured at the end of the reperfusion. The phosphorylation of Akt, $GSK-3{\beta}$, and MAPK kinases (ERK1/2, P38 and JNK) was determined by Western blotting after 10 min of reperfusion. EGCG reduced the infarct size compared with the control ($25.4{\pm}9.2$ versus $43.2{\pm}8.2$ %, p<0.05). Wortmannin alone did not affect the infarct size, but abolished the EGCG-induced infarct size limiting effect, indicating that EGCG may protect the heart by modulating the PI3K-Akt. EGCG significantly enhanced the phosphorylation of Akt and $GSK-3{\beta}$ but not ERK1/2, while it reduced that of p38 and JNK. These results suggest that EGCG has a protective effect against regional myocardial I/R injuries through activation of the RISK pathway and attenuation of p38 and JNK. EGCG may have cardioprotective effects in patients undergoing surgeries prone to myocardial I/R injuries.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0