지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
A simultaneous detection and quantification method for determining the Phenylalkylamine derivatives, such as methamphetamine (MA), amphetamine (AM), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), ketamine (KT), norketamine (NKT), phentermine (PT), fenfluramine (FFA) and phenmetrazine (PM), in oral fluid was developed and validated according to international guidelines. The validated method was applied to actual oral fluid samples collected from drug abuse suspects. The recovery of phenylalkylamines from oral fluid collection devices was also assessed. Oral fluid specimens from 20 drug abuse suspects submitted by the police were collected using Salivette$^{TM}$, Quantisal$^{TM}$ or direct expectoration. The samples were screened using a biochip array analyzer. For confirmation, the samples were analyzed by GC-MS in selected-ion monitoring (SIM) mode after extraction using automated SPE with a mixed-mode cation exchange cartridge and derivatization with trifluoroacetic anhydride (TFAA). The results from the immunoassay were consistent with those from GC-MS. All the oral fluid samples gave positive results for MA, AM, PT and/or PM. The detection of phenylalkylamines in oral fluid can provide a better indication of recent use than urine or hair. Therefore, the oral fluid specimen was useful for demonstrating phenylalkylamines abuse in the driving under the influence of drug (DUID) as an alternative specimen for urine.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Richard, A. G / 1989 / Pharmacology and toxicology of amphetamine and related designer drugs in NIDA Research Monograph 94 / US Department of Health and Human Services, Rockville :43
Logan, B. K / 2001 / Amphetamines: an update on forensic issues / J. Anal. Toxicol 25:400
Maxwell, J. C / 2005 / Emerging research on methamphetamine / Curr. Opi. Psychiatry 18:235
Kalant, H / 2001 / The pharmacology and toxicology of 'ecstacy' (MDMA) and related drugs / Canadian Medical Association Journal 165:917
Steel, T. D / 1994 / 3,4- Methylenedioxymeth amphetamine (MDMA, 'Ecstacy'): pharmacology and toxicology in animals and humans / Addiction 89:539
Logan, B. K / 2001 / Amphetamines: an update on forensic issues / J. Anal. Toxicol 25:400
Maxwell, J. C / 2005 / Emerging research on methamphetamine / Curr. Opi. Psychiatry 18:235
Kalant, H / 2001 / The pharmacology and toxicology of 'ecstacy' (MDMA) and related drugs / Canadian Medical Association Journal 165:917
Steel, T. D / 1994 / 3,4- Methylenedioxymeth amphetamine (MDMA, 'Ecstacy'): pharmacology and toxicology in animals and humans / Addiction 89:539
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