지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
To search the minimum structural requirement of tricyclic isoxazole analogues (1~30) as new class potent antidepressant, thee-dimensional quanti- tative-structure relationship (3D-QSAR) models between substituents ($R_1{\sim}R_5$) of tricyclic isoxazoles and their antidepressant activity against medetomidine-induced loss of righting were performed and discussed quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indies analysis (CoMSIA) methods. The correlativity and predictability ($r^2$=0.484 and $q^2$=0.947) of CoMSIA-2 model were higher than those of the rest models. The inhibitory activity against medetomidine-induced loss of righting was dependent on electrostatic field (43.4%), hydrophobic field (35.3%), and steric field (21.2%) of tricyclic isoxazoles. From the CoMSIA-2 contour maps, it is predicted that the antidepressant activity of potent antidepressants against medetomidine-induced loss of righting will be able to increase by the substituents ($R_1{\sim}R_5$) which were in accord with CoMSIA field.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Nestler, E. J / 2002 / Neurobiology of depression / Neuron 34:13
Hindmarch, I / 2001 / Expanding the horizons of depression: beyond the monoamine hypothesis / Hum. Psychopharmacol 16:203
French, N / 1995 / lpha 2-adrenoceptors and I2 sites in the mammalian central nervous system / Pharmacol. Ther 68:175
Bylund, D. B / 1988 / Subtypes of alpha 2-adrenoceptors: pharmacological and molecular biological evidence converge. Trends / Pharmacol. Sci 9:356
Bylund, D. B / 1992 / Subtypes of alpha 1- and alpha 2-adrenergic receptors / FASEB J 6:832
Hindmarch, I / 2001 / Expanding the horizons of depression: beyond the monoamine hypothesis / Hum. Psychopharmacol 16:203
French, N / 1995 / lpha 2-adrenoceptors and I2 sites in the mammalian central nervous system / Pharmacol. Ther 68:175
Bylund, D. B / 1988 / Subtypes of alpha 2-adrenoceptors: pharmacological and molecular biological evidence converge. Trends / Pharmacol. Sci 9:356
Bylund, D. B / 1992 / Subtypes of alpha 1- and alpha 2-adrenergic receptors / FASEB J 6:832
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