지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Clematis mandshurica (Ranunculaceae) has traditionally been used as a remedy for antidiuretic, antifungal, rheumatic conditions and alleviate pain. We carried out to evaluate the anti-oxidative effect, anti-inflammatory effect and anti-melanogenic effect of ethanol extract and solvent fractions of Clematis mandshurica. The ethanol extract and the dichloromethane fraction of Clematis mandshurica showed an anti-oxidative effect in DPPH assay, the inhibitory activity of nitric oxide (NO) production in lipopolysaccharide (LPS) activated RAW 264.7 cell, and melanin synthesis and tyrosinase activity of B16F10 melanoma cells. They reduced NO production and melanin content in a dose-dependent manner at concentrations of $2.5{\sim}10{\mu}g/ml$. They also suppressed iNOS and tyrosinase protein and m-RNA expressions dose dependently, assayed by western blot analysis and RT-PCR experiment.
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참고문헌 (19)
참고문헌 신청
이창복 / 1980 / 대한식물도감 / 향문사 :303
Park, E. K. / 2006 / Anti-inflammatory effects of an ethanolic extract from Clematis mandshurica Rupr / J. of Ethnopharmacol 108:142
Ding, Q. / 2009 / Cytotoxic and antibacterial triterpenoids derivatives from Clematis ganpiniana / J. of Ethnopharmacol 126:382
Shi, S. / 2006 / Triterpene Saponins from Clematis mandshurica / J. Nat. Prod 69:1591
Du, Z. / 2003 / Two new antifungal saponins from the tibetan herbal medicine Clematis tangutica / Planta Med 69:547
Park, E. K. / 2006 / Anti-inflammatory effects of an ethanolic extract from Clematis mandshurica Rupr / J. of Ethnopharmacol 108:142
Ding, Q. / 2009 / Cytotoxic and antibacterial triterpenoids derivatives from Clematis ganpiniana / J. of Ethnopharmacol 126:382
Shi, S. / 2006 / Triterpene Saponins from Clematis mandshurica / J. Nat. Prod 69:1591
Du, Z. / 2003 / Two new antifungal saponins from the tibetan herbal medicine Clematis tangutica / Planta Med 69:547
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