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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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The aim of this study was to investigate the prevalence of quinolone resistant E. coli from retail meat and to characterize the resistant determinants. Determination of minimum inhibitory concentration, the sequence analysis of gyrA, gyrB, parC, and parE quinolone resistance determining regions (QRDR), the presences of plasmid mediated quinolone resistance (PMQR) and the expression of efflux pump genes were investigated. Of the total 277 retail meat samples, 67 coli form bacteria were isolated. 15 of 67 isolates showed nalidixic acid resistance and 7 of 15 nalidixic acid resistant isolates were also resistant to ciprofloxacin, moxifloxacin and levofloxacin. 11 of 15 nalidixic acid resistant strains were isolated from chicken, 2 of 15 were isolated from beef and 2 of 15 were isolated from pork samples. 11 of 15 nalidixic acid resistant strains have single mutation at codon 87 (D87N or D87G) in gyrA, 2 of 11 gyrA mutants have double mutations at codon 86 and 87 (L86A and L87I) in parC with mutations at codon 434+445+465 or 429 in gyrB. 2 of 15 resistant isolates harbored qnrS, a PMQR determinant. Over expression of the acrB gene, efflux pump gene (3.93~16.53 fold), was observed in 10 of 15 resistant isolates.
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참고문헌 (32)
참고문헌 신청
EMA / 2012 / Sales of veterinary antimicrobial agents in 19 EU/EEA countries in 2010
임숙경 / 2014 / 국내 가축 및 수산에서 항생제 판매 추이(2003-2012) / 대한수의학회지 54(2):81~86
Aaerestrup, F. M / 1999 / Association between the consumption of antimicrobial agents in animal husbandry and the occurrence of resistant bacteria among food animals / Int. J. Antimicrob. Agents 12:279
Jacoby, G. A / 2005 / Mechanism of resistance to quinolones / Clin. Infec. Dis 41:120
Hernández-Allés, S / 1999 / Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes, Antimicrob / Antimicrob. Agents Chemother 43:937
임숙경 / 2014 / 국내 가축 및 수산에서 항생제 판매 추이(2003-2012) / 대한수의학회지 54(2):81~86
Aaerestrup, F. M / 1999 / Association between the consumption of antimicrobial agents in animal husbandry and the occurrence of resistant bacteria among food animals / Int. J. Antimicrob. Agents 12:279
Jacoby, G. A / 2005 / Mechanism of resistance to quinolones / Clin. Infec. Dis 41:120
Hernández-Allés, S / 1999 / Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes, Antimicrob / Antimicrob. Agents Chemother 43:937
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