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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제4호
- 발행연도
- 2008.1
- 수록면
- 415 - 418 (4page)
이용수
초록· 키워드
오류제보하기
Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: $p53^{-/-}$, c-myc, K-ras) and C2 (genotype: $p53^{-/-}$, c-myc, Akt), with $ED_{50}$ values of 0.58 ${\mu}M$ (C1) and 10.7 ${\mu}M$ (C2).
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